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Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.
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  • Gianfranco Umeres-Francia1,
  • María Rojas-Fernández,
  • Percy Herrera Añazco,
  • Vicente Benites-Zapata
Gianfranco Umeres-Francia1
Universidad Peruana de Ciencias Aplicadas
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María Rojas-Fernández
Universidad Peruana de Ciencias Aplicadas
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Percy Herrera Añazco
Hospital Nacional 2 de mayo
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Vicente Benites-Zapata
Universidad San Ignacio de Loyola
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Abstract

Objective: To assess the association between NLR and PLR with all-cause mortality in Peruvian patients with CKD Methods: We conducted a retrospective cohort study in adults with CKD in stages 1 to 5. The outcome variable was mortality and as variables of exposure to NLR and PLR. Both ratios were categorized as high with a cut-off point of 3.5 and 232.5; respectively. We carried out a Cox regression model and calculated crude and adjusted hazard ratios (HR) with their 95% confidence interval (95%CI). Results: We analyzed 343 participants with a median follow-up time of 2.45 years (2.08-3.08). The frequency of deaths was 17.5% (n=60). In the crude analysis, the high NLR and PLR were significantly associated with all-cause mortality (HR=2.01; 95% CI:1.11-3.66) and (HR=2.58; 95% CI:1.31-5.20). In the multivariate model, after adjusting for age, sex, serum creatinine, CKD stage, albumin and hemoglobin, the high NLR and PLR remained as an independent risk factor for all-cause mortality, (HR=2.10; 95% CI:1.11-3.95) and (HR=2.71; 95% CI:1.28-5.72). Conclusion: Our study suggests the relationship between high NLR and PLR with all-cause mortality in patients with CKD.

Peer review status:UNDER REVIEW

12 Jan 2021Submitted to International Journal of Clinical Practice
13 Jan 2021Assigned to Editor
13 Jan 2021Submission Checks Completed
02 Feb 2021Reviewer(s) Assigned