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Milrinone in the treatment of Persistent Pulmonary Hypertension of the Newborn: A Case Series
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  • Norbert Dera,
  • Lukasz Osinski,
  • Piotr Jurkowski,
  • Anna Doboszynska,
  • Slawomir Szajda,
  • Alina Minarowska
Norbert Dera
Regional Specialist Hospital in Olsztyn
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Lukasz Osinski
Regional Specialist Hospital in Olsztyn
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Piotr Jurkowski
University of Warmia and Mazury in Olsztyn School of Medicine
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Anna Doboszynska
University of Warmia and Mazury in Olsztyn School of Medicine
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Slawomir Szajda
University of Warmia and Mazury in Olsztyn School of Medicine
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Alina Minarowska
University of Warmia and Mazury in Olsztyn School of Medicine
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Abstract

Persistent Pulmonary Hypertension of the Newborn (PPHN) is defined as a failure of the normal circulatory transition after birth. PPHN manifests as a progressive and potentially fatal hypoxemic respiratory failure. The condition is associated with a persistent increase in pulmonary vascular resistance and reduced blood flow in the pulmonary vessels without an accompanying congenital heart defect. The abnormalities in pulmonary circulation lead to right-to-left shunting through the foramen ovale and usually also through the ductus arteriosus, with resultant hypoxemia, which manifests clinically as cyanosis. Management options in PPHN include optimal lung inflation, oxygenation, prevention of acidosis, stabilization of blood pressure, sedation and pulmonary vasodilator therapy. While inhaled nitric oxide (iNO) is the most commonly used treatment option, alternative methods can be used whenever is unavailable or contraindicated. We report three cases of severe PPHN, in which due to the lack of adequate response to intravenous MgSO4, the patients were switched to milrinone.

Peer review status:IN REVISION

01 Feb 2021Submitted to Pediatric Pulmonology
02 Feb 2021Assigned to Editor
02 Feb 2021Submission Checks Completed
04 Feb 2021Reviewer(s) Assigned
17 Feb 2021Review(s) Completed, Editorial Evaluation Pending
21 Feb 2021Editorial Decision: Revise Major