loading page

Evaluation of Dynamic / Thiol Disulfide Balance and İschemia Modified Albumin in Children with Trauma
  • +11
  • CAN OZTORUN,
  • HAYAL DORUK,
  • DOĞUŞ GÜNEY,
  • ÜLFET NİHAL İRDEM KÖSE,
  • TUĞBA ÖRNEK DEMİR,
  • VİLDAN SELİN ÇAYHAN,
  • SABRİ DEMİR,
  • Ahmet ERTÜRK,
  • ALİ GÜNGÖR,
  • AYSUN KARA UZUN,
  • CEMİL NURAL,
  • Salim Neselioglu,
  • Mujdem Nur Azili,
  • EMRAH SENEL
CAN OZTORUN
Ankara Yildirim Beyazit University
Author Profile
HAYAL DORUK
Ankara City Hospital
Author Profile
DOĞUŞ GÜNEY
Ankara Yildirim Beyazit University
Author Profile
ÜLFET NİHAL İRDEM KÖSE
Ankara City Hospital
Author Profile
TUĞBA ÖRNEK DEMİR
Ankara City Hospital
Author Profile
VİLDAN SELİN ÇAYHAN
Ankara City Hospital
Author Profile
SABRİ DEMİR
Ankara City Hospital
Author Profile
Ahmet ERTÜRK
Ankara City Hospital
Author Profile
ALİ GÜNGÖR
Ankara City Hospital
Author Profile
AYSUN KARA UZUN
Ankara City Hospital
Author Profile
CEMİL NURAL
Ankara Yildirim Beyazit University
Author Profile
Salim Neselioglu
Yildirim Beyazit University Faculty of Medicine
Author Profile
Mujdem Nur Azili
Ankara Yildirim Beyazit University
Author Profile
EMRAH SENEL
Ankara Yildirim Beyazit University
Author Profile

Abstract

Introduction: Trauma is the most common cause of death in childhood. Tissue damage, ischemia-reperfusion injury and inflammatory response are mainly responsible for increasing serbest oxiygen radicals. In this study, we aimed to investigate the use of thiol-disulfide and ischemia-modified albumin levels as a diagnostic laboratory parameter in trauma children. Method: Of 202 children, 101 of them were hospitalized in pediatric surgical intensive care unit with trauma and 101 of others were healthy children. Levels of native thiol (-SH), total thiol (SH + SS), dynamic disulfide (SS), dynamic disulfide (SS) / total thiol (SH + SS), albumin and ischemic modified albumin (IMA) were measured from the sera of patients and healthy volunteers. For statistical analyses, SPSS 17.0 was used. Mann-Whitney U and paired correlation test were used where appropriate. p <0.05 was considered significant. Results: The mean age of the patients in the trauma group (Boys: 61 Girls: 40) was 7,88 years and the control group was 8,00 years. In trauma group, 86 of children were exposed to blunt trauma, 15 of children had penetrating trauma and 54 patients had multiple trauma. Surgical procedures were performed in 17 patients. In the trauma group, native thiol, total thiol, dynamic disulfide / total thiol, albumin and IMA levels were significantly lower than that of control (p <0.001) and their dynamic disulfide (p = 0.001) was higher compared to the control. There was no difference thiol-disulfide parametres in trauma groups sub-division as surgery(n=17) vs. follow-up(n=84) groups or multiple trauma(n=54) vs. isolated organ trauma(n=47) groups, or penetrating(n=15) or blunt trauma(n=86) groups. Conclusion: Thiol-disulfide balance and IMA levels show changes in favor of oxidative stress in children with trauma, however, it cannot be used as a laboratory marker that helps to show the system and organ affected by the trauma and to decide the surgical intervention.

Peer review status:UNDER REVIEW

26 Dec 2020Submitted to International Journal of Clinical Practice
05 Jan 2021Submission Checks Completed
05 Jan 2021Assigned to Editor
05 Feb 2021Reviewer(s) Assigned
01 Mar 2021Review(s) Completed, Editorial Evaluation Pending
17 Apr 20211st Revision Received
22 Apr 2021Submission Checks Completed
22 Apr 2021Assigned to Editor
01 Jun 2021Reviewer(s) Assigned