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Thrombotic Microangiopathy: Multi-Institutional Review of Pediatric Patients Who Underwent HSCT
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  • Archana Ramgopal,
  • Shiva Sridhar,
  • Jignesh Dalal,
  • Ram Kalpatthi
Archana Ramgopal
Children's Hospital of Pittsburgh of UPMC
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Shiva Sridhar
UH Rainbow Babies and Children's Hospital
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Jignesh Dalal
UH Rainbow Babies and Children's Hospital
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Ram Kalpatthi
Children's Hospital of Pittsburgh of UPMC
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Abstract

Thrombotic microangiopathy (TMA) is a rare but serious complication of hematopoietic stem cell transplantation (HSCT). The purpose of our study is to estimate the incidence and risk factors of TMA in 93 out of a total of 12369 children (0.8%) receiving HSCT. HHV6 infection was an independent risk factor associated with increased mortality in patients with TMA (Hazard Ratio: 2.86 [1.01, 8.39], p=0.05), and our study conducts a review of the literature with the association of HHV-6 and complement activation. Studies exploring the pathophysiology of TMA and its relationship to HSCT are needed to optimize the outcome of pediatric patients.