loading page

Epstein-Barr virus induced sickle hepatopathy
  • Alison Towerman,
  • David Wilson,
  • Monica Hulbert
Alison Towerman
Washington University in Saint Louis School of Medicine
Author Profile
David Wilson
Washington University in Saint Louis School of Medicine
Author Profile
Monica Hulbert
Washington University in Saint Louis School of Medicine
Author Profile

Abstract

Sickle hepatopathy comprises a spectrum of disorders that vary in severity. Intravascular sickling and sinusoidal occlusion are the principal drivers of sickle hepatopathy, but infection or autoimmunity may act as triggers. We describe two cases of acute sickle hepatopathy initiated by primary Epstein-Barr virus (EBV) infection, a previously unreported association. The first case entailed a 14-year-old girl with hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis that responded to a simple transfusion of erythrocytes. The second case was that of a 16-year-old boy with HbSC disease who experienced life-threatening intrahepatic cholestasis with multi-organ failure.

Peer review status:ACCEPTED

09 Feb 2021Submitted to Pediatric Blood & Cancer
09 Feb 2021Submission Checks Completed
09 Feb 2021Assigned to Editor
12 Feb 2021Reviewer(s) Assigned
09 Mar 2021Review(s) Completed, Editorial Evaluation Pending
10 Mar 2021Editorial Decision: Revise Major
26 May 20211st Revision Received
26 May 2021Submission Checks Completed
26 May 2021Assigned to Editor
02 Jun 2021Reviewer(s) Assigned
10 Jun 2021Review(s) Completed, Editorial Evaluation Pending
12 Jun 2021Editorial Decision: Accept