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Patient selection for LIVE therapy - From clinical indications to multimodality imaging individual case planning
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  • Paulo Neves,
  • Thasee Pillay,
  • Lon Annest,
  • Kevin Van Bladel,
  • Erhard Kaiser,
  • Fabian Stahl,
  • Thorsten Hanke,
  • Martin Swaans,
  • Patrick Klein,
  • Tobias Ruf,
  • Ralph Stephan von Bardeleben
Paulo Neves
Centro Hospitalar de Vila Nova de Gaia Espinho EPE
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Thasee Pillay
BioVentrix Inc
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Lon Annest
BioVentrix Inc
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Kevin Van Bladel
BioVentrix Inc
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Erhard Kaiser
Private Practice for Internal Medicine and Cardiology
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Fabian Stahl
Kardiologie am Tibarg
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Thorsten Hanke
Asklepios Hospital Harburg
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Martin Swaans
St.Antonius Hospital
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Patrick Klein
St.Antonius Hospital
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Tobias Ruf
Universitätsmedizin Mainz
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Ralph Stephan von Bardeleben
Universitätsmedizin Mainz
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Abstract

Background LIVE (Less Invasive Ventricular Enhancement) with Revivent TC™ is an innovative therapy for symptomatic ischemic Heart Failure (HF). It is designed to reconstruct a negatively remodeled left ventricle (LV) after an anterior myocardial infarction (MI) by plication of the scar tissue. Its indications are specific and, as with any other structural heart intervention, the success of the procedure starts with appropriate patient selection. We aim to present the indications of the technique, crucial aspects in patient selection and individual case planning approach. Methods and Results After clinical evaluation, transthoracic echocardiography is the first imaging modality to be performed in a potential candidate for the therapy. However, definitive indication and detailed case planning rely on late gadolinium-enhanced cardiac magnetic resonance imaging or multiphasic contrast-enhanced cardiac computed tomography. These imaging modalities also assist with relative or absolute contra-indications for the procedure. Individual assessment is done to tailor the procedure to the specifics of the LV anatomy and location of the myocardial scar. Conclusion LIVE procedure is a unique intervention to treat symptomatic heart failure and ischemic cardiomyopathy after anterior MI. It is a highly customizable intervention that allows a patient-tailored approach, based on multimodality imaging assessment and planification.

Peer review status:IN REVISION

06 Feb 2021Submitted to Echocardiography
06 Feb 2021Submission Checks Completed
06 Feb 2021Assigned to Editor
13 Feb 2021Reviewer(s) Assigned
15 May 2021Review(s) Completed, Editorial Evaluation Pending
01 Jun 2021Editorial Decision: Revise Minor
21 Jun 20211st Revision Received
23 Jun 2021Assigned to Editor
23 Jun 2021Submission Checks Completed