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Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments
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  • Zahra Taherizadeh,
  • shayan rahmani,
  • Fatemeh Alidadi,
  • Khadijeh Esmaeilpour
Zahra Taherizadeh
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shayan rahmani
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Fatemeh Alidadi
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Khadijeh Esmaeilpour
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Objective: During the COVID-19 pandemic, quarantine and staying at home is advised. The social relationship between people has become deficient, and human social isolation (SI) has become the consequence of this situation. It was shown that SI has made changes in hippocampal neuroplasticity, which will lead to poor cognitive function and behavioral abnormalities. There is a connection between SI, learning, and memory impairments. In addition, anxiety-like behavior and increased aggressive mood in long-term isolation have been revealed during the COVID-19 outbreak. Methods: Term searches was done in Google Scholar, Scopus, ScienceDirect, Web of Science and PubMed databases as well as hand searching in key resource journals from 1979–2020. Results: Studies have shown that some drug administrations may positively affect or even prevent social isolation consequences in animal models. These drug treatments have included opioid drugs, anti-depressants, Antioxidants, and herbal medications. In addition to drug interventions, there are non-drug treatments that include an enriched environment, regular exercise, and music. Conclusion: This manuscript aims to review improved cognitive impairments induced by SI during COVID-19.

Peer review status:UNDER REVIEW

20 Feb 2021Submitted to International Journal of Clinical Practice
22 Feb 2021Assigned to Editor
22 Feb 2021Submission Checks Completed
23 Feb 2021Reviewer(s) Assigned
07 Apr 2021Review(s) Completed, Editorial Evaluation Pending