Reverse Impaired Fasting Glucose in Overweight and Obese Patients
Participating in a Self-Paid University Weight Management Program
Abstract
Aims: The progression of prediabetes to T2DM can be delayed through diet
modification and weight management. This retrospective review examines
the impact on blood sugar, blood pressure, and fasting lipids of a
self-pay weight management program utilizing protein-enriched meal
replacements and partial meal replacement diets providing 2.2
grams/kg/day of protein in overweight and obese patients with impaired
fasting glucose and excess body fat (average %body fat ca. 40%).
Methods: The medical records of 4634 obese patient who participated in
the self-pay UCLA Weight Management Program were reviewed to identify
2572 eligible patients for this retrospective study of the impact of
weight loss over 3 months on patients with normal fasting glucose (NFG)
(n=1396) or impaired fasting glucose (IFG) (n=1176). Results: Patients
with IFG lost comparable amounts of weight (ca. 10 kg) at three months
as did the subjects with NFG. Fasting blood glucose in the IFG group
decreased from 108.49 ± 6.4 mg/dl to 101.8 ±9.41 mg/dl
(p<0.0001) after three months. There were also significant
reductions in triglycerides, and both systolic and diastolic blood
pressure in both groups in association with weight loss. Conclusion: Our
medically supervised self-pay multidisciplinary weight management
program utilizing protein-enriched diets and meal replacements reduced
fasting blood glucose levels in patients with IFG while reducing
triglycerides and blood pressure in all patients over three months.