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Prognostic Value of C-Reactive Protein to Albumin Ratio in Patients Resuscitated from Out-of-Hospital Cardiac Arrest
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  • Tuğba Bingol Tanriverdi,
  • Gulcin Patmano,
  • Firdevs Tugba Bozkurt,
  • Bedri Caner Kaya,
  • Mehmet Tercan
Tuğba Bingol Tanriverdi
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Gulcin Patmano
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Firdevs Tugba Bozkurt
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Bedri Caner Kaya
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Mehmet Tercan
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Abstract

Background: Despite major advances in basic and advanced life supports, patients who survived from out of hospital cardiac arrest (OHCA) has still poor prognosis. Several inflammatory parameters have been used to determine early and long-term prognosis in patients with OHCA. C-reactive protein-to-albumin ratio (CAR) is also a novel marker of systemic inflammation. To our knowledge, there is no study evaluating the clinical importance of CAR in OHCA patients. Aims: To evaluate the effect of CAR on mortality in patients with OHCA. Methods: A total of 102 patients with OHCA were included in this study. The study population were divided into two groups as survivor (n = 43) and non-survivor (n = 59) during follow-up. Complete blood cell counts, biochemical and blood gas analysis were recorded for all patients. Neutrophil to lymphocyte ratio (NLR) was calculated as the ratio of neutrophil to lymphocyte. CAR was calculated as the ratio of CRP to the albumin. Results: NLR (P=0.012), CAR (P<0.001) and serum lactate level (P =0.002) were significantly higher whereas lymphocyte (P=0.008) and serum albumin (P<0.001) were significantly lower in non-survivor group compared to survivor group. Multivariate logistic regression analysis showed that NLR (odds ratio [OR]: 1.044, 95% confidence interval [CI]: 1.044-1.437, P=0.013), CAR (OR: 1.971, 95% CI: 1.327-2.930, P=0.001), and lactate level (OR: 1.268, 95% CI: 1.095-1.469, P=0.002) were independent predictors of mortality. Conclusions: We have demonstrated for the first time that CAR was an independent predictor of in-hospital mortality in OHCA patients.

Peer review status:ACCEPTED

10 Jan 2021Submitted to International Journal of Clinical Practice
11 Jan 2021Submission Checks Completed
11 Jan 2021Assigned to Editor
27 Feb 2021Reviewer(s) Assigned
17 Mar 2021Review(s) Completed, Editorial Evaluation Pending
24 Mar 20211st Revision Received
25 Mar 2021Submission Checks Completed
25 Mar 2021Assigned to Editor
31 Mar 2021Reviewer(s) Assigned
05 Apr 2021Review(s) Completed, Editorial Evaluation Pending
12 Apr 2021Editorial Decision: Accept