Background and Aims: As a result of the current demographics, increased projections of atherosclerotic cardiovascular disease (ASCVD) and prevalence of the disease in Latin America (LA), a panel of multidisciplinary experts developed a review of ASCVD in this Region considering the available and appropriate diagnostic methods, classifying the disease and initiating appropriate treatment. The panel expects to increase the awareness of this prevalent disease, decrease consequences of ASCVD with corresponding cost savings and, ultimately, decrease the overall burden of ASCVD in LA. Methods: A selected panel of Latin American experts in fields related to ASCVD were provided with a series of relevant questions to address prior to the multi-day conference. Within this conference, each narrative was discussed and edited by the entire group, through numerous drafts and rounds of discussion until a consensus was achieved. Results: The authors propose specific and realistic recommendations for increasing the awareness of ASCVD in LA and in other countries in a similar situation. Moreover, in creating these recommendations, the authors strived to address all barriers and impediments mentioned previously within this review. Conclusion: This manuscript provides a review of the current state of ASCVD in LA. Additionally, the panel proposes practical recommendations that should be implemented throughout the Region in order to decrease the burden of ASCVD and effectively preventing the consequences in future generations. These recommendations can serve as a framework for LA and other countries in similar situations.