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Risk of sick sinus syndrome in patients diagnosed with atrial fibrillation: a population-based cohort
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  • Pil-Sung Yang,
  • Daehoon Kim,
  • Eunsun Jang,
  • Hee Tae Yu,
  • Tae-Hoon Kim,
  • Jung-Hoon Sung,
  • Hui-Nam Pak,
  • Moon-Hyoung Lee,
  • Boyoung Joung
Pil-Sung Yang
CHA Bundang Medical Center
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Daehoon Kim
Yonsei University Health System
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Eunsun Jang
Yonsei University Health System
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Hee Tae Yu
Yonsei University College of Medicine
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Tae-Hoon Kim
Yonsei University Health System
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Jung-Hoon Sung
Bundang CHA Medical Center, CHA University, Seongnam
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Hui-Nam Pak
Yonsei University Health System
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Moon-Hyoung Lee
Yonsei Cardiovascular Center and Cardiovascular Research
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Boyoung Joung
Yonsei Cardiovascular Center and Cardiovascular Research
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Abstract

Background: Sinoatrial node dysfunction and atrial fibrillation (AF) frequently coexist and interact with each other, often to initiate and perpetuate each other. Objective: To determine the effect of AF on the incidence and risk of sick sinus syndrome (SSS). Methods: The association of incident AF with the development of incident SSS was assessed from 2004 to 2013 in 302,229 SSS- and pacemaker-free participants aged ≥60 years in the Korea National Health Insurance Service-Senior cohort. Results: During an observation period of 1,854,800 person-years, incident AF was observed in a total of 12,797 participants (0.69%/year). The incidence of SSS was 0.2 and 3.4 per 1000 person-years in the incident AF and the propensity score matched no-AF groups, respectively. After adjustment, the risk of SSS caused by incident AF was significantly increased, with a hazard ratio (HR) of 13.4 (95% confidence interval [CI]: 8.4–21.4). This finding was consistently observed after censoring for heart failure (HR, 16.0; 95% CI: 9.2–28.0) or heart failure/myocardial infarction (HR, 16.6; 95% CI: 9.3-29.7). Incident AF also was associated with an increased risk of pacemaker implantation related with both SSS (HR, 21.8; 95% CI: 8.7–18.4) and atrioventricular (AV) block (HR, 9.5; 95% CI: 4.9–18.4). These results were consistent regardless of sex and comorbidities. Conclusion: Incident AF was associated with more than ten times increased risk of SSS in an elderly population regardless of comorbidities. Risk of pacemaker implantations related with both sinus node dysfunction and AV block were increased in elderly population with incident AF.

Peer review status:IN REVISION

06 Mar 2021Submitted to Journal of Cardiovascular Electrophysiology
10 Mar 2021Assigned to Editor
10 Mar 2021Submission Checks Completed
12 Mar 2021Reviewer(s) Assigned
05 Apr 2021Review(s) Completed, Editorial Evaluation Pending
08 Apr 2021Editorial Decision: Revise Minor