Nitrogen-Containing Metabolic Stressors Stimulate High-value Compounds
Accumulation in Arthrospira platensis
Abstract
Suitable conditions for high-value compounds hyperaccumulation are the
most challenging approach in Arthrospira platensis. In the current
study, the co-production of specialty pigments and high-value
metabolites was investigated with a varying concentration of well-known
and candidate metabolic stressors in Arthrospira platensis.
Supplementing Arthrospira platensis with a minimum of 0.50% of
Monosodium glutamate (MSG) and a maximum of 2% of aspartate (ASP)
increased Phycocyanin productivity by 83.36 and 64.77 percent,
respectively. However, a maximum of 1.50% of MSG and a minimum of
0.50% ASP increased carotenoid content by 188.80 and 68.97 percent,
respectively. These observations, coupled with those showing
supplemented ASP stimulate unsaturated fatty acid accumulation, possibly
through enhanced de novo biosynthesis, and essential amino acid
biosynthesis to a greater extent in Arthrospira platensis. A network
correlation analysis also indicated the distinct metabolite abundance
and the corresponding associated metabolic networks linked to pigment
production in Arthrospira platensis.