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Nitrogen-Containing Metabolic Stressors Stimulate High-value Compounds Accumulation in Arthrospira platensis
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  • Farzaneh Fekrat,
  • Maryam Shahbazi,
  • Behnam Nami,
  • Mohammad Amin Hejazi,
  • Mohammad Reza Ghaffari
Farzaneh Fekrat
Agricultural Biotechnology Research Institute of Iran
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Maryam Shahbazi
Agricultural Biotechnology Research Institute of Iran
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Behnam Nami
Agricultural Biotechnology Research Institute of Iran
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Mohammad Amin Hejazi
Agricultural Biotechnology Research Institute of Iran
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Mohammad Reza Ghaffari
Agricultural Biotechnology Research Institute of Iran
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Abstract

Suitable conditions for high-value compounds hyperaccumulation are the most challenging approach in Arthrospira platensis. In the current study, the co-production of specialty pigments and high-value metabolites was investigated with a varying concentration of well-known and candidate metabolic stressors in Arthrospira platensis. Supplementing Arthrospira platensis with a minimum of 0.50% of Monosodium glutamate (MSG) and a maximum of 2% of aspartate (ASP) increased Phycocyanin productivity by 83.36 and 64.77 percent, respectively. However, a maximum of 1.50% of MSG and a minimum of 0.50% ASP increased carotenoid content by 188.80 and 68.97 percent, respectively. These observations, coupled with those showing supplemented ASP stimulate unsaturated fatty acid accumulation, possibly through enhanced de novo biosynthesis, and essential amino acid biosynthesis to a greater extent in Arthrospira platensis. A network correlation analysis also indicated the distinct metabolite abundance and the corresponding associated metabolic networks linked to pigment production in Arthrospira platensis.