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Reinforcement-based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models
  • Karolina Noworyta,
  • Agata Cieslik,
  • Rafal Rygula
Karolina Noworyta
Maj Institute of Pharmacology Polish Academy of Sciences
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Agata Cieslik
Maj Institute of Pharmacology Polish Academy of Sciences
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Rafal Rygula
Maj Institute of Pharmacology Polish Academy of Sciences
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Abstract

Alcohol use disorder (AUD) is one of the most common but still poorly treated psychiatric conditions. Developing new treatments requires a better understanding of the aetiology of symptoms and evaluation of novel therapeutic targets in preclinical studies. Recent developments in our understanding of the reinforcement-based cognitive biases (RBCBs) that contribute to the development of AUD and its treatment offer new opportunities for both clinical and preclinical research. In this review, we first briefly describe psychological and cognitive theories that implicate various aspects of reinforcement sensitivity in the development, maintenance, and recurrence of alcohol addiction. Furthermore, in separate sections, we describe studies investigating RBCBs and their neural, neurochemical, and pharmacological correlates, and we discuss possible interactions between RBCBs and trajectories of AUD. Finally, we describe how recent translational studies using state-of-the-art animal models can facilitate our understanding of the role of reinforcement sensitivity and RBCBs in various aspects of AUD.

Peer review status:IN REVISION

11 Mar 2021Submitted to British Journal of Pharmacology
12 Mar 2021Assigned to Editor
12 Mar 2021Submission Checks Completed
15 Mar 2021Reviewer(s) Assigned
27 Apr 2021Review(s) Completed, Editorial Evaluation Pending
28 Apr 2021Editorial Decision: Revise Minor
04 Jun 20211st Revision Received