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Gut microbiota and bronchopulmonary dysplasia
  • Kun Yang,
  • Shasha He,
  • WENBIN DONG
Kun Yang
The Affiliated Hospital of Southwest Medical University
Author Profile
Shasha He
The Affiliated Hospital of Southwest Medical University
Author Profile
WENBIN DONG
The Affiliated Hospital of Southwest Medical University
Author Profile

Abstract

Bronchopulmonary dysplasia is a relatively common and severe complication of prematurity, and its pathogenesis remains ambiguous. Revolutionary advances in microbiological analysis techniques, together with the growing sophistication of the gut-lung axis hypothesis, have resulted in more studies linking gut microbiota dysbiosis to the occurrence and development of bronchopulmonary dysplasia. The present article builds on current findings to examine the intrinsic associations between gut microbiota and bronchopulmonary dysplasia. The gut microbiota affects bronchopulmonary dysplasia via several potential mechanisms including alteration of the gut-lung axis, promotion of inflammation and the ensuing growth effects, therefore these are also investigated. By evaluating the potential mechanisms, new therapeutic targets and potential therapeutic modalities for BPD can be identified from a microecological perspective.

Peer review status:ACCEPTED

18 Mar 2021Submitted to Pediatric Pulmonology
19 Mar 2021Submission Checks Completed
19 Mar 2021Assigned to Editor
19 Mar 2021Reviewer(s) Assigned
01 Apr 2021Review(s) Completed, Editorial Evaluation Pending
03 Apr 2021Editorial Decision: Revise Major
02 May 20211st Revision Received
03 May 2021Submission Checks Completed
03 May 2021Assigned to Editor
03 May 2021Reviewer(s) Assigned
14 May 2021Review(s) Completed, Editorial Evaluation Pending
16 May 2021Editorial Decision: Accept