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The first reported case of Noonan syndrome complicated with hepatocellular carcinoma.
  • +11
  • Satoru Kakizaki,
  • Daisuke Uehara,
  • Hiroki Tojima,
  • Takayoshi Suga,
  • Yuichi Yamazaki,
  • Ken Sato,
  • Norio Kubo,
  • Ken Shirabe,
  • Takayuki Yokota,
  • Kei Shibuya,
  • Tatsurou Maehara,
  • Hideaki Yokoo,
  • Atsushi Naganuma,
  • Toshio Uraoka
Satoru Kakizaki
National Hospital Organization Takasaki General Medical Center
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Daisuke Uehara
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Hiroki Tojima
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Takayoshi Suga
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Yuichi Yamazaki
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Ken Sato
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Norio Kubo
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Ken Shirabe
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Takayuki Yokota
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Kei Shibuya
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Tatsurou Maehara
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Hideaki Yokoo
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Atsushi Naganuma
National Hospital Organization Takasaki General Medical Center
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Toshio Uraoka
Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu
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Abstract

Noonan syndrome is a genetic multisystem disorder characterized by distinctive facial features, developmental delay, congenital heart disease, and other conditions. It is associated with mutation of genes encoding the proteins in the RAS-MAPK pathway, including PTPN11. We herein describe the first case of Noonan syndrome complicated with hepatocellular carcinoma.

Peer review status:ACCEPTED

17 Mar 2021Submitted to Clinical Case Reports
18 Mar 2021Submission Checks Completed
18 Mar 2021Assigned to Editor
20 Mar 2021Reviewer(s) Assigned
31 Mar 2021Review(s) Completed, Editorial Evaluation Pending
06 Apr 2021Editorial Decision: Revise Minor
07 Apr 20211st Revision Received
12 Apr 2021Submission Checks Completed
12 Apr 2021Assigned to Editor
12 Apr 2021Review(s) Completed, Editorial Evaluation Pending
26 Apr 2021Editorial Decision: Accept