loading page

Antibiotic Stewardship Program’s potential impacts on financial and clinical outcomes in a public hospital: a Real-World study
  • +6
  • Rodrigo Garbero,
  • Nathalia Lobão Barroso de Souza Silveira,
  • Analice Alves Simões,
  • Gabriela Alves Martins,
  • Ludmilla Vale da Cruz,
  • Vinícius Gabriel Monteiro von Zuben,
  • Camila Serra Rodrigues,
  • Natan da Silva,
  • Derek Chaves Lopes
Rodrigo Garbero
Base Hospital of the Federal District

Corresponding Author:[email protected]

Author Profile
Nathalia Lobão Barroso de Souza Silveira
Base Hospital of the Federal District
Author Profile
Analice Alves Simões
Superior School of Health Sciences
Author Profile
Gabriela Alves Martins
Superior School of Health Sciences
Author Profile
Ludmilla Vale da Cruz
Superior School of Health Sciences
Author Profile
Vinícius Gabriel Monteiro von Zuben
Superior School of Health Sciences
Author Profile
Camila Serra Rodrigues
Superior School of Health Sciences
Author Profile
Natan da Silva
Superior School of Health Sciences
Author Profile
Derek Chaves Lopes
Superior School of Health Sciences
Author Profile

Abstract

Background: In times of antibiotic resistance, Antimicrobial Stewardship Programs (ASP) emerge as a strategy to improve clinical outcomes and hospital resource management. Methods: The study was conducted on a single-center retrospective cohort of adult inpatients admitted to a public hospital in Brazil’s capital and submitted to ASP from September 2018 to April 2019, aiming to assess the clinical and economic impact of following ASP instructions. Results: The medical records of 449 patients were included. Mean age was 54.92 years, with a predominance of male sex 273 (60.93%), and 374 (83.48%) had comorbidities. Only 52.56% of the prescriptions followed the guidelines of ASP. The study demonstrated a significant improvement in clinical outcomes, such as a reduction of mortality (p=0.01), of hospital length of stay (p<0.01) and of ICU admissions (p<0.01). We also detected potential savings per patient provided by compliance with ASP’s recommendations. Conclusion: The present study was able to demonstrate positive clinical outcomes associated with the implementation of an ASP in a real-world scenario.