Antibiotic Stewardship Program’s potential impacts on financial and
clinical outcomes in a public hospital: a Real-World study
Abstract
Background: In times of antibiotic resistance, Antimicrobial Stewardship
Programs (ASP) emerge as a strategy to improve clinical outcomes and
hospital resource management. Methods: The study was conducted on a
single-center retrospective cohort of adult inpatients admitted to a
public hospital in Brazil’s capital and submitted to ASP from September
2018 to April 2019, aiming to assess the clinical and economic impact of
following ASP instructions. Results: The medical records of 449 patients
were included. Mean age was 54.92 years, with a predominance of male sex
273 (60.93%), and 374 (83.48%) had comorbidities. Only 52.56% of the
prescriptions followed the guidelines of ASP. The study demonstrated a
significant improvement in clinical outcomes, such as a reduction of
mortality (p=0.01), of hospital length of stay (p<0.01) and of
ICU admissions (p<0.01). We also detected potential savings
per patient provided by compliance with ASP’s recommendations.
Conclusion: The present study was able to demonstrate positive clinical
outcomes associated with the implementation of an ASP in a real-world
scenario.