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Epigenetic evidence of malignant carcinoma and skin melanoma neoplasms concomitantly in the thyroid
  • +6
  • Ali Al-Harake,
  • Israa Dandache,
  • Hiba Moukadem ,
  • Marwan Saliba ,
  • Jimmy Chahine ,
  • Hosni Yazbeck ,
  • Fadi Abdel-sater ,
  • Hussein Karnib ,
  • Mahmoud Younes
Ali Al-Harake
Department of Surgery, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
Israa Dandache
Department of Life and Earth Sciences, Faculty of Sciences I, Lebanese University, Beirut, Lebanon

Corresponding Author:[email protected]

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Hiba Moukadem
Department of Oncology, Saint George Hospital, Baabda, Lebanon
Marwan Saliba
Medical Research Center, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
Jimmy Chahine
Department of Surgery, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
Hosni Yazbeck
Medical Research Center, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
Fadi Abdel-sater
Department of Biochemistry, Faculty of Sciences I, Lebanese University, Beirut, Lebanon
Hussein Karnib
Medical Research Center, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
Mahmoud Younes
Medical Research Center, Al Rassoul Al Aazam Hospital, Beirut, Lebanon
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Abstract

The study investigates the case of a total thyroidectomy, where after dissection multiple nodules showed two malignant patterns by immunohistochemistry. Molecular analysis based on DNA methylation profile was used to further inspect the origin of the coexisting neoplasms. We confirmed the presence of malignant skin melanoma involving medullary thyroid cancer.

Peer review status:ACCEPTED

24 Dec 2020Submitted to Clinical Case Reports
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28 Dec 2020Submission Checks Completed
28 Dec 2020Assigned to Editor
23 Mar 2021Reviewer(s) Assigned
27 Apr 2021Review(s) Completed, Editorial Evaluation Pending
16 May 2021Editorial Decision: Revise Minor
25 Jul 20211st Revision Received
26 Jul 2021Submission Checks Completed
26 Jul 2021Assigned to Editor
26 Jul 2021Review(s) Completed, Editorial Evaluation Pending
15 Aug 2021Editorial Decision: Accept