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Is There any Effect of lycopene’s preventing peritoneal adhesion formation in rats: An Experimental Study
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  • Ahmet Bilgi,
  • Mustafa Cosan Terek,
  • Gurkan Yigitturk,
  • Dilek Taskıran,
  • Orkun İlgen,
  • İsmet Hortu,
  • mehmet kulhan
Ahmet Bilgi
Selçuk University Faculty of Medicine
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Mustafa Cosan Terek
Ege Universitesi Tip Fakultesi
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Gurkan Yigitturk
Mugla Sitki Kocman University Faculty of Medicine
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Dilek Taskıran
Ege Universitesi Tip Fakultesi
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Orkun İlgen
Dokuz Eylul University Faculty of Medicine
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İsmet Hortu
Ege Universitesi Tip Fakultesi
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mehmet kulhan
Selcuk Universitesi Tip Fakultesi
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Abstract

Objective Purpose of the study; to demonstrate the effects of lycopene on the prevention of intraabdominal adhesions in rats with biochemical, histological and macroscopic parameters. Material methods Twenty eight rats were divided into four groups consisting of 7 rats each. Group 1 [only adhesion], Group 2 [adhesion+corn oil], Group 3 [adhesion+ 5 mg/kg lycopene], Group 4 [ adhesion+20 mg / kg lycopene]. Macroscopic adhesion score, histopathological examination, Vascular endothelial growth factor (VEGF) H-score, malondialdehyde, total anioxidant capacity and VEGF values were measured in the groups. Results There were significantly higher extend [P < 0.05], severity [P < 0.05], degree [P < 0.05] and total adhesion [P < 0.05] scores in the control group and corn-oil group than in the low lycopene group and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When low lycopene group and high lycopene group were compared in terms of anti VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control group and high lycopene group [p<0.05]. Conclusion Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.