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How we approach coagulopathy with vascular anomalies.
  • Joana Mack,
  • Shelley Crary
Joana Mack
Arkansas Children's Hospital
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Shelley Crary
University of Arkansas for Medical Sciences
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Abstract

Some vascular anomalies can present with challenging hematologic aberrations. Kaposiform hemangioendothelioma (KHE) may be complicated with Kasabach-Merritt phenomenon (KMP) and stagnant blood flow in slow flow malformations can promote activation and consumption of coagulation factors which results in bleeding and clotting known as localized intravascular coagulopathy (LIC). These patients can experience significant morbidity secondary to pain due to thrombosis and are at higher risk of hematologic complications during surgical procedures. No standard of care has been established to prevent or manage these complications. This review focuses on the management of coagulopathy in children and adults with vascular anomalies.

Peer review status:IN REVISION

07 Apr 2021Assigned to Editor
07 Apr 2021Submission Checks Completed
07 Apr 2021Submitted to Pediatric Blood & Cancer
08 Apr 2021Reviewer(s) Assigned
12 May 2021Review(s) Completed, Editorial Evaluation Pending
12 May 2021Editorial Decision: Revise Minor