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Time-sensitive effects of Zhuang Medicated Thread Moxibustion on Estrogen Level in female perimenopausal Model Rats.
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  • Dan Liang,
  • Yun Zhang,
  • Zhiyong Cao,
  • Jingqing Chen,
  • Zhuli Hou,
  • Yuhan Pan,
  • Ke Lu,
  • Gang Fang
Dan Liang
GuangXi University of Chinese Medicine
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Yun Zhang
GuangXi University of Chinese Medicine
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Zhiyong Cao
Hubei Minzu University
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Jingqing Chen
GuangXi University of Chinese Medicine
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Zhuli Hou
Hubei Minzu University
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Yuhan Pan
GuangXi University of Chinese Medicine
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Ke Lu
GuangXi University of Chinese Medicine
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Gang Fang
GuangXi University of Chinese Medicine
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Abstract

Abstract Background: To ascertain the estrogenic effect of Zhuang Medicated Thread Moxibustion (ZMTM) and explore its time-sensitive impact on estradiol in female perimenopausal rats. Methods: Female rats were randomized into four groups of 10 rats, each consisting of the control, model, ZMTM, and acupuncture groups. The perimenopausal syndrome was induced in the last three groups with a daily subcutaneous dose of 80 mg/kg of 4- vinylcyclohexene diepoxide for 15 days. Afterward, rats in the model and control groups were fed routinely, while rats in the ZMTM and acupuncture groups were treated with six ZMTM and acupuncture courses, respectively. The rats’ general condition and estradiol (E2) levels in the rats’ serum were assessed. Results: Following the six courses of treatment, the E2 level in the model group was significantly the lowest, while the regular group was the highest (P < 0.05). There was also a gradual increase in the E2 level of the ZMTM group compared to the model and acupuncture groups, such that after the 5th and 6th courses of treatment, their E2 level was significantly higher than the model and acupuncture groups (P < 0.05). The control group had a better condition than all other groups, while the ZMTM group was better than the model and acupuncture groups. Conclusion: ZMTM can improve perimenopausal induced rats’ estrogen level, and this effect becomes better with each further treatment course.

Peer review status:IN REVISION

08 Apr 2021Submitted to International Journal of Clinical Practice
09 Apr 2021Assigned to Editor
09 Apr 2021Submission Checks Completed
09 Apr 2021Reviewer(s) Assigned
07 May 2021Review(s) Completed, Editorial Evaluation Pending
07 May 2021Editorial Decision: Revise Minor