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Patho-immunological mechanisms of vitiligo: an integration of the immunogenetic milieu, with innate and adaptive immunities, as triggered by environmental stress factors
  • Safa Faraj,
  • E H Kemp,
  • DAVID GAWKRODGER
Safa Faraj
The University of Sheffield
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E H Kemp
University of Sheffield
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DAVID GAWKRODGER
UNIV OF SHEFFIELD
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Abstract

Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emo-tional stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative stress in pigment cells which secrete damage-associated molecular patterns that then initiate innate immune responses. Antigen presentation to melanocytes leads to stim-ulation of autoreactive T cell responses, with further targeting of pigment cell. Studies show a pathogenic basis for cellular stress, innate immune responses and adaptive immun-ity in vitiligo. Improved understanding of the aetiological mechanisms in vitiligo has already resulted in successful use of the Jak-1 inhibitors in vitiligo. In this review we outline the cur-rent understanding of the pathological mechanisms in vitiligo, and locate loci to which therapeutic attack might be directed.

Peer review status:IN REVISION

02 Apr 2021Submitted to Clinical & Experimental Immunology
07 Apr 2021Assigned to Editor
07 Apr 2021Submission Checks Completed
09 Apr 2021Reviewer(s) Assigned
04 May 2021Review(s) Completed, Editorial Evaluation Pending
04 May 2021Editorial Decision: Revise Major