loading page

Non-ribosomal insights into ribosomal P2 protein in Plasmodium falciparum-infected erythrocytes
  • Sudipta Das,
  • Bhaskar Roy,
  • Saswata Chakrabarty
Sudipta Das
CSIR-Indian Institute of Chemical Biology
Author Profile
Bhaskar Roy
CSIR-Indian Institute of Chemical Biology
Author Profile
Saswata Chakrabarty
CSIR-Indian Institute of Chemical Biology
Author Profile

Abstract

The enormous complexity of the eukaryotic ribosome has been a real challenge in unlocking the mechanistic aspects of its amazing molecular function during mRNA translation and many non-canonical activities of ribosomal proteins in eukaryotic cells. While exploring the uncanny nature of ribosomal P proteins in malaria parasites Plasmodium falciparum, the 60S stalk ribosomal P2 protein has been shown to get exported to the infected erythrocyte (IE) surface as an SDS resistant oligomer during the early to mid trophozoite stage. Inhibiting IE surface P2 either by monoclonal antibody or through genetic knockdown resulted in nuclear division arrest of the parasite. This very strange and serendipitous finding has led us to explore more about un-canonical cell biology and structural involvement of P2 protein in Plasmodium in the search for a novel biochemical role during parasite propagation in the human host.

Peer review status:ACCEPTED

08 Apr 2021Submitted to MicrobiologyOpen
09 Apr 2021Assigned to Editor
09 Apr 2021Submission Checks Completed
09 Apr 2021Reviewer(s) Assigned
10 Apr 2021Review(s) Completed, Editorial Evaluation Pending
10 Apr 2021Editorial Decision: Accept