loading page

Dynamic thiol/disulphide balance in patients undergoing hypotensive anesthesia in elective septoplasties
  • +7
  • Leyla Kazancioglu,
  • Sule Batcik,
  • Medeni Arpa,
  • Basar Erdivanli,
  • Zerrin Ozergin Coskun,
  • Ozlem Celebi Erdivanli,
  • Ilkay Bahceci,
  • Hizir Kazdal,
  • Ozcan Erel,
  • Salim Neselioglu
Leyla Kazancioglu
Recep Tayyip Erdogan Universitesi Tip Fakultesi
Author Profile
Sule Batcik
Author Profile
Medeni Arpa
Recep Tayyip Erdoğan Üniversitesi
Author Profile
Basar Erdivanli
Recep Tayyip Erdoğan Üniversitesi
Author Profile
Zerrin Ozergin Coskun
Recep Tayyip Erdoğan Üniversitesi
Author Profile
Ozlem Celebi Erdivanli
Recep Tayyip Erdogan Universitesi
Author Profile
Ilkay Bahceci
Recep Tayyip Erdogan Universitesi
Author Profile
Hizir Kazdal
Recep Tayyip Erdoğan University
Author Profile
Ozcan Erel
Yildirim Beyazit Universitesi
Author Profile
Salim Neselioglu
Yildirim Beyazit University
Author Profile

Abstract

Objective: We aimed to investigate the effects of hypotensive anesthesia on oxidative stress with serum thiol/disulfide balance in patients undergoing elective septoplasty procedures under general anesthesia. Methods: Seventy-two patients between the ages of 18-60, with a physical condition I –II, according to the American Society of Anesthesiologists, were included in this prospective observational study. Septoplasty was chosen for standard surgical stress. According to the maintenance of anesthesia, patients were divided into the groups as Hypotensive Anesthesia (n = 40) and Normotensive Anesthesia (n = 32). Serum thiol/disulfide levels were measured by the method developed by Erel & Neşelioğlu. Results: The native thiol and total thiol values of both groups measured at the 60th minute intraoperatively were significantly lower than the preoperative values (both p < 0.01). Intraoperatively, at the 60th minute, there was no significant difference in terms of post-native thiol and post-total thiol levels between hypotensive and normotensive anesthesia groups (p = 0.68, and p = 0.81, respectively). Age > 40 years and female gender were found to have a significant effect on dynamic oxidative stress (p = 0.002, and p = 0.001, respectively). Conclusion: This pilot study has found that hypotensive anesthesia had no adverse effect on dynamic thiol/disulfide balance in elective surgeries.

Peer review status:UNDER REVIEW

21 Mar 2021Submitted to International Journal of Clinical Practice
22 Mar 2021Assigned to Editor
22 Mar 2021Submission Checks Completed
10 Apr 2021Reviewer(s) Assigned