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LESSONS FOR COVID 19 ERA: IMPACT OF DELAYS IN SURGERY ON BIOCHEMICAL RECURRENCE-FREE SURVIVAL AND ADVERSE ONCOLOGICAL OUTCOMES IN PROSTATE CANCER PATIENTS
  • +8
  • Bahadir Sahin,
  • Ozan Bozkurt,
  • Sinan Sözen,
  • Haluk Ozen,
  • Bulent Akdogan,
  • Guven Aslan,
  • Volkan Izol,
  • Sumer Baltacı,
  • Levent Turkeri,
  • Serdar Çelik,
  • Ilker Tinay
Bahadir Sahin
Marmara Universitesi Tip Fakultesi
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Ozan Bozkurt
Dokuz Eylül University
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Sinan Sözen
Gazi University
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Haluk Ozen
Hacettepe University Faculty of Medicine
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Bulent Akdogan
Hacettepe University
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Guven Aslan
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Volkan Izol
Cukurova University Faculty of Medicine
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Sumer Baltacı
Ankara University Faculty of Medicine
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Levent Turkeri
Acibadem University
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Serdar Çelik
Izmir Bozyaka Training and Research Hospital
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Ilker Tinay
Marmara University School of Medicine
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Abstract

OBJECTIVE To assess the impact of the surgical delay for localized prostate cancer (PCa) on adverse pathological features and oncological outcomes. MATERIALS AND METHODS Patients who underwent surgery for localized prostate cancer were included from the Turkish Urooncology Association (TUA) Prostate Cancer database. A History of previous treatment or active surveillance (AS) were considered as exclusion criteria from the study. Patients were divided into two groups according the time period between the diagnosis and surgery; less than or equal to 90 days (group 1) or longer than 90 days (group 2). Surgical pathology results and oncological outcomes were compared between the two groups. RESULTS A total of 2454 out of 3646 patients were assessed. Pathological findings of the radical prostatectomy (RP) specimens were similar between two groups. However, there was slightly more seminal vesicle invasion in final surgical pathology in group 1 (12.9% vs. 9.3%, respectively p=0.042). 5-year biochemical recurrence free survival times were similar across all D’Amico risk categories between two groups. The regression analysis demonstrated the seminal vesicle invasion as the only factor affecting time to PSA progression in high-risk patients (p<0.001 HR:2.51 CI: 1,58-4,45). CONCLUSION In conclusion, our results in this large cohort suggest that surgical delay does not cause a deterioration for prostate cancer surgical outcomes even in high-risk group of patients. These findings may be helpful for planning the limited healthcare resources especially in conditions like the Covid-19 pandemic where the availability and optimal use of healthcare system resources is crucial.