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Thromboinflammation in COVID-19: The Clot Thickens
  • Raayma Iffah,
  • Felicity Gavins
Raayma Iffah
Brunel University
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Felicity Gavins
Brunel University
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Abstract

Since the start of the novel coronavirus SARS-Cov-2 pandemic, a disease that has become one of the world’s greatest global health challenges, the role of the immune system has been at the forefront of scientific studies. The pathophysiology of COVID-19 is complex, which is evident by those at higher risk for poor outcome. Multiple systems contribute to thrombosis and inflammation seen in COVID-19 patients, including neutrophil dysfunction, platelet activation, endothelial cell activation. Understanding how the immune system functions in different patient cohorts (particularly given recent emerging events with the Oxford/AstraZeneca vaccine) is vital to understanding the pathophysiology of this devastating disease and for subsequent development of novel therapeutic targets and expedite possible drug repurposing strategies that could benefit society on a global scale.

Peer review status:ACCEPTED

04 Apr 2021Submitted to British Journal of Pharmacology
13 Apr 2021Submission Checks Completed
13 Apr 2021Assigned to Editor
18 Apr 2021Reviewer(s) Assigned
26 Apr 2021Review(s) Completed, Editorial Evaluation Pending
27 Apr 2021Editorial Decision: Revise Minor
16 May 20211st Revision Received
21 May 2021Submission Checks Completed
21 May 2021Assigned to Editor
23 May 2021Review(s) Completed, Editorial Evaluation Pending
27 May 2021Editorial Decision: Accept