loading page

Title: A new era of atopic eczema research: Advances and highlights
  • +1
  • Claudia Hülpüsch,
  • Andreas Weins,
  • Claudia Traidl-Hoffmann,
  • Matthias Reiger
Claudia Hülpüsch
University of Augsburg Faculty of Medicine
Author Profile
Andreas Weins
University Hospital Augsburg
Author Profile
Claudia Traidl-Hoffmann
University of Augsburg Faculty of Medicine
Author Profile
Matthias Reiger
University of Augsburg Faculty of Medicine
Author Profile

Abstract

Atopic eczema (AE) is an inflammatory skin disease with involvement of genetic, immunological, and environmental factors. One hallmark of AE is a skin barrier disruption on multiple, highly interconnected levels: filaggrin mutations, increased skin pH, and a microbiome dysbiosis towards Staphylococcus aureus overgrowth are observed in addition to an abnormal type 2 immune response. Extrinsic factors seem to play a major role in the development of AE. As AE is a first step in the atopic march, its prevention and appropriate treatment is essential. Although standard therapy remains topical treatment, powerful systemic treatment options emerged in the last years. However, thorough endotyping of the individual patients is still required for ideal precision medicine approaches in the future. Therefore, novel microbial and immunological biomarkers were described recently for the prediction of disease development and treatment response. This review summarizes the current state of the art in AE research.

Peer review status:IN REVISION

03 May 2021Submitted to Allergy
04 May 2021Assigned to Editor
04 May 2021Submission Checks Completed
05 May 2021Reviewer(s) Assigned
21 May 2021Review(s) Completed, Editorial Evaluation Pending
26 May 2021Editorial Decision: Revise Minor