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Macrophage Activation Syndrome in Two Infants with Multisystem Inflammatory Syndrome in Children
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  • MIGUEL GARCIA DOMINGUEZ,
  • Cynthia Torres,
  • Juan Carreón-Guerrero,
  • Jose Quibrera,
  • Daniela Arce-Cabrera,
  • Marco Yamazaki-Nakashimada
MIGUEL GARCIA DOMINGUEZ
Hospital Pediatrico de Sinaloa
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Cynthia Torres
Hospital Pediatrico de Sinaloa
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Juan Carreón-Guerrero
Hospital Pediatrico de Sinaloa
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Jose Quibrera
Hospital Pediatrico de Sinaloa
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Daniela Arce-Cabrera
Hospital Pediatrico de Sinaloa
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Marco Yamazaki-Nakashimada
National Institute of Pediatrics
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Abstract

Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection with clinical features of Kawasaki-like disease was reported in various pediatric centers in late April 2020. Currently, cases have increased throughout the world with a range of manifestations from less to greater severity. However, hemophagocytosis has not been described in patients with MIS-C. We describe two infants diagnosed with MIS-C who presented Macrophage Activation Syndrome (MAS) with hemophagocytosis documented in the bone marrow. MIS-C can be complicated with MAS, the key features for diagnosis are splenomegaly, hypofibrinogenemia, hypertriglyceridemia and bone marrow hemophagocytosis. Cytokine storm and MAS in MIS-C may represent part of the spectrum of the disease and HScore could be of value in order to give timely and aggressive treatment.

Peer review status:ACCEPTED

03 May 2021Submitted to Pediatric Blood & Cancer
03 May 2021Submission Checks Completed
03 May 2021Assigned to Editor
05 May 2021Reviewer(s) Assigned
27 May 2021Review(s) Completed, Editorial Evaluation Pending
27 May 2021Editorial Decision: Revise Major
02 Jun 2021Submission Checks Completed
02 Jun 2021Assigned to Editor
02 Jun 20211st Revision Received
17 Jun 2021Review(s) Completed, Editorial Evaluation Pending
17 Jun 2021Editorial Decision: Accept