Activation of the Hedgehog and Wnt/β-catenin Signaling Pathways in the
Immunohistochemistry of Basal Cell Carcinoma
Immunohistochemical studies have revealed that the tumor of a patient
with basal cell carcinoma exhibited activation of the Hedgehog and
Wnt/β-catenin signaling pathways. The glioma-associated oncogene1
overexpression leads to transcriptional activation making it an
attractive molecular target in anticancer therapies due to the main
downstream effectors of the cascade.