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Can HLA type I and II alleles presence be associated with the clinical spectrum of CHIKV infection?
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  • Juan C. Rueda,
  • Ana M. Santos,
  • Jose-Ignacio Angarita,
  • Eugenia-Lucia Saldarriaga,
  • Ingris Peláez-Ballestas,
  • Alejandro Silva Espinosa,
  • Ignacio Briceño-Balcázar,
  • Sofia Arias-Correal,
  • José Arias Correal,
  • Catalina Villota-Erazo,
  • Viviana Reyes,
  • Santiago Bernal-Macías,
  • Mario H. Cardiel,
  • John Londono
Juan C. Rueda
Student from the Biosciences Programme Faculty of Medicine and Engineering Universidad de La Sabana Chía Colombia
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Ana M. Santos
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Jose-Ignacio Angarita
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Eugenia-Lucia Saldarriaga
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Ingris Peláez-Ballestas
Hospital General de Mexico Dr Eduardo Liceaga
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Alejandro Silva Espinosa
Grupo de Genética Humana Universidad de La Sabana Chía Colombia
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Ignacio Briceño-Balcázar
Grupo de Genética Humana Universidad de La Sabana Chía Colombia
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Sofia Arias-Correal
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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José Arias Correal
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Catalina Villota-Erazo
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Viviana Reyes
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Santiago Bernal-Macías
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Mario H. Cardiel
Centro de Investigación Clínica de Morelia SC Morelia Mexico
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John Londono
Grupo de Espondiloartropatías Rheumatology Department Universidad de La Sabana Chía Colombia
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Abstract

Host immune response as well as virulence factors are key in disease susceptibility. There are no known association studies of HLA class I and II alleles with chikungunya (CHIKV) infection in Latin American population. We aim to identify Human Leukocyte Antigen (HLA) alleles present in patients with CHIKV infection when compared to healthy controls, as well as allele association with the clinical spectrum of the disease. A cross-sectional analysis nested in a community cohort was carried out. We included patients 18 years and older with serological confirmation of CHIKV infection. HLA typing of HLA-A, HLA-B and HLA-DRB1 alleles was performed. Two-by-two tables were used to establish associations between allele presence and clinical characteristics. Data from 65 patients with confirmed CHIKV infection were analyzed for HLA typing. CHIKV infection was associated with the presence of HLA-A*68, HLA-B*35, HLA-DRB*01, HLA-DRB1*04 and HLA-DRB1*13 alleles with statistical significance when compared to healthy subjects. A statistically significant relationship was found between the presence of rash in the face or the abdomen and the presence of HLA-DRB1*04. Our study demonstrated that in our cohort, HLA type I as well as type II alleles are associated with CHIKV infection, and specifically an HLA type II allele with dermatological symptoms. Further research is needed to set a path for future investigation on genes outside the HLA system to improve knowledge in the pathophysiology of CHIKV infection and its host-pathogen interaction.

Peer review status:IN REVISION

30 Apr 2021Submitted to Transboundary and Emerging Diseases
02 May 2021Assigned to Editor
02 May 2021Submission Checks Completed
12 May 2021Reviewer(s) Assigned
04 Jun 2021Review(s) Completed, Editorial Evaluation Pending
04 Jun 2021Editorial Decision: Revise Minor