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Stretch-driven microfluidic chip for nucleic acid detection
  • +5
  • Xiang Li,
  • Xiaoyu Zhao,
  • Weihao Yang,
  • Fei Xu,
  • Bailiang Chen,
  • Jiwei Peng,
  • Jiajun Huang,
  • Shengli Mi
Xiang Li
Tsinghua University Graduate School at Shengzhen
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Xiaoyu Zhao
Tsinghua University Graduate School at Shengzhen
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Weihao Yang
Tsinghua University Graduate School at Shengzhen
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Fei Xu
Tsinghua University Graduate School at Shengzhen
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Bailiang Chen
Tsinghua University Graduate School at Shengzhen
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Jiwei Peng
Tsinghua University Graduate School at Shengzhen
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Jiajun Huang
Tsinghua Shenzhen International Graduate School
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Shengli Mi
Tsinghua Shenzhen International Graduate School
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Abstract

Molecular diagnosis is an essential means to detect pathogens. The portable nucleic acid detection chip has excellent prospects in places where medical resources are scarce, and it is also of research interest in the field of microfluidic chips. Here, the paper developed a new type of microfluidic chip for nucleic acid detection where stretching acts as the driving force. The sample entered the chip by applying capillary force. The strain valve was opened under the action of tensile force, and the spring pump generated the power to drive the fluid to flow to the detection chamber in a specific direction. The detection of COVID-19 was realized on the chip. The RT-LAMP amplification system was adopted to observe the liquid color in the detection chamber to decide whether the sample tested positive or negative qualitatively.

Peer review status:ACCEPTED

12 May 2021Submitted to Biotechnology and Bioengineering
12 May 2021Assigned to Editor
12 May 2021Submission Checks Completed
13 May 2021Reviewer(s) Assigned
20 May 2021Review(s) Completed, Editorial Evaluation Pending
20 May 2021Editorial Decision: Accept