Respiratory outcomes at five-year follow-up in children with MBL
deficiency: a cohort study
Abstract
Introduction Mannose-binding lectin (MBL) serum protein, is an important
molecule of the innate immune system that is involved in antimicrobial
recognition and clearing responses. There is no conclusive evidence that
MBL deficiency is associated with adverse respiratory consequences. Aim
We explored whether there is a difference in clinical, radiological and
microbiological characteristics in children with MBL deficiency
presenting with troublesome respiratory symptoms (frequent, recurrent,
persistent or very severe), as compared to those who are MBL-sufficient.
Methods We performed a retrospective study looking at MBL measurements
in children over a period of 10 years in a large teaching hospital, with
a minimum follow-up period of 5 years from the time of the MBL
measurement to the year 2019. Results 32% of children with MBL
deficiency and 30% of those with MBL sufficiency had positive
microbiology. 23% of children with MBL deficiency and 24% of those
with MBL sufficiency had radiological changes on plain radiographs. 28%
of children with MBL deficiency and 33% of those with MBL sufficiency
had suboptimal vaccine responses to primary immunisations. 67% of the
MBL-deficient children had suboptimal vaccine responses to booster
immunisations, compared to 40% of the MBL-sufficient group. Conclusion
We conclude that there is no difference at five year follow-up in
clinical, radiological and microbiological characteristics between
children who are MBL-deficient as compared to those who have sufficient
levels. These results add to the existing body of literature that shows
no statistically significant association between MBL deficiency and
susceptibility to recurrent respiratory tract infection in children.