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Thin endometrial thickness is a risk factor for singleton low birth weight from single blastocyst transfer: A retrospective cohort study
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  • Mingze Du,
  • Junwei Zhang,
  • Manman Liu,
  • Xingling Wang
Mingze Du
Third affiliated hospital of Zhengzhou University
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Junwei Zhang
The Third Affiliated Hospital of Zhengzhou University
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Manman Liu
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Xingling Wang
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Abstract

Objective To explore whether thin endometrial thickness (EMT) is associated with singleton low birth weight (LBW) from single fresh blastocyst transfer. Design Retrospective cohort study. Setting Reproductive center. Population All women were ≤40 years old and underwent single fresh blastocyst transfer and singleton live birth. Interventions None. Methods Multivariable logistic regression was used to evaluate the association between thin EMT and singleton LBW. Main outcome measures LBW was the primary concern of this study. Results In total, 2847 women met the study inclusion criteria. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm group (P<0.001). The rate of LBW in the EMT ≤7.5 mm group was 24.9%, which was significantly higher than the 4.0% in the EMT 7.6~12.0 mm group and the 5.3% in the EMT >12.0 mm group (P<0.001). The total neonatal malformation rate was similar between the groups (1.1%, 0.8% and 1.5%, P=0.21). After multiple logistic regression analysis, EMT≤7.5 mm was an independent risk factor for LBW (adjusted odds ratio [AOR]: 4.39, 95% CI: 1.85~10.46, P<0.001). Conclusions Thin EMT (≤7.5 mm) on the hCG trigger day is an independent risk factor for singleton LBW from single fresh blastocyst transfer. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm groups. The total neonatal malformation rate was comparable between the groups.

Peer review status:UNDER REVIEW

22 May 2021Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
23 May 2021Assigned to Editor
23 May 2021Submission Checks Completed
26 May 2021Reviewer(s) Assigned