Abstract
Background: In 1965 Altman achieved the hippocampal neurogenesis in
rats. In addition, when enough activities are provided in the daytime,
and it is suggested that the consolidation of the memory during sleep
will be achieved by hippocampal neurogenesis. Aims: We show a recovery
method about dementia of neurodegenerative diseases on this article. We
introduce our clinical practice of the chronobiological therapy
regarding 6 dementia cases. Method: We provided the chronobiological
therapy based on awakening-sleep rhythm by daily medical care. We
examined autonomic nervous disorders and fluctuating cognition using
physical examination. We performed the medication to promote the changes
from sleep to awakening-activities in morning. In daytime, our
occupational therapy was set, and awakening-activities was made stable.
At night we gave the medication to make an active state decreased and
stabilize deep sleep. The clinical evaluation was carried out by
psychological examination. And Voxel-based Specific Regional Analysis
System for Alzheimer’s Disease (VSRAD) of Magnetic Resonance Imaging
(MRI), which had been already established, was performed. The
conventional study in VSRAD showed the state that the brain atrophy was
progressive. Results: About Z-score showing the hippocampal atrophy in
VSRAD we accomplished the improvement of 1.28 points from 0.03 about six
dementia cases by the chronobiological therapy. These improvements were
accompanied by the better changes of the cognitive functions.
Conclusion: We speculate that the hippocampal neurogenesis may be
derived by reconstructing awakening-sleep rhythm using the
chronobiological medicines. If neurogenesis is more dominant than
neurodegeneration, dementia associated with the neurodegeneration can be
treated.