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Incidence density of influenza illness during pregnancy in Suzhou, China, 2015--2018
  • +15
  • Liling Chen,
  • Suizan Zhou,
  • Lin Bao,
  • Alexander Millman,
  • Zhongwei Zhang,
  • Yan Wang,
  • Yayun Tan,
  • Ying Song,
  • Pengwei Cui,
  • Yuanyuan Pang,
  • Cheng Liu,
  • Jiangchun Qin,
  • Ping Zhang,
  • Mark Thompson,
  • Angela Iuliano,
  • Ran Zhang,
  • Carolyn Greene,
  • Jun Zhang
Liling Chen
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Suizan Zhou
Centers for Disease Control and Prevention
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Lin Bao
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Alexander Millman
Centers for Disease Control and Prevention
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Zhongwei Zhang
Suzhou Municipal Hospital, Suzhou, Jiangsu Province, P.R. China
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Yan Wang
Wuzhong Maternal and Child Health Care Institute, Suzhou, Jiangsu Province, P.R. China
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Yayun Tan
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Ying Song
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Pengwei Cui
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Yuanyuan Pang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Cheng Liu
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Jiangchun Qin
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Ping Zhang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Mark Thompson
Centers for Disease Control and Prevention
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Angela Iuliano
CDC
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Ran Zhang
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Carolyn Greene
U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA
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Jun Zhang
Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu Province, P.R. China
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Abstract

Background: Data on influenza incidence during pregnancy in China are limited. Methods: From October 2015–September 2018, we conducted active surveillance for acute respiratory illness (ARI) among women during pregnancy. Nurses conducted twice weekly phone and text message follow-up upon enrollment until delivery to identify new episodes of ARI. Nasal and throat swabs were collected ≤10 days from illness onset to detect influenza. Results: In total, we enrolled 18,724 pregnant women median aged 28yo, 37% in first trimester, 48% in second trimester and 15% in third trimester, with 7 self-reported vaccination during pregnancy. In the 18-week epidemic period during October 2015–September 2016, influenza incidence was 0.7/100 person-months (95% CI:0.5–0.9). In the 29-week epidemic during October 2016–September 2017, influenza incidence was 1.0/100 person-months (95% CI:0.8–1.2). In the 11-week epidemic period during October 2017–September 2018, influenza incidence was 2.1/100 person-months (95% CI:1.9–2.4). Influenza incidence was similar by trimester. More than half of the total influenza illnesses had no elevated temperature and cough. Most influenza-associated ARIs were mild, and <5.1% required hospitalization. Conclusions: Influenza illness in all trimesters of pregnancy was common. These data may help inform decisions regarding the use of influenza vaccine to prevent influenza during pregnancy.

Peer review status:IN REVISION

26 May 2021Submitted to Influenza and other respiratory viruses
27 May 2021Assigned to Editor
27 May 2021Submission Checks Completed
02 Jun 2021Editorial Decision: Revise Minor
09 Jun 20211st Revision Received