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Does diabetic early kidney damage alter renal elasticity?: An ultrasound based 2D Shear wave elastography study
  • Nesrin Gündüz,
  • Aysenur Buz,
  • Adnan Kabaalioglu
Nesrin Gündüz
Istanbul Medeniyet University Faculty of Medicine
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Aysenur Buz
Istanbul Medeniyet University Faculty of Medicine
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Adnan Kabaalioglu
Koc University
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Abstract

Objectives: Kidney damage caused by type-II diabetes mellitus (DM-II) can disturb renal elasticity. There is a paucity of data whether early kidney damage causes kidney stiffening. This comparative study aimed to assess kidney elasticity in patients with DM-II with or without moderate albuminuria using ultrasound based 2D shear wave velocity (2D-SWV). Methods: For this prospective single center study, a sample size of at least 32 was computed. Overall 57 cases (40 DM-II subjects with no chronic kidney disease and 17 age and sex matched healthy controls) were included. The DM-II subjects comprised moderate albuminuria (n=22) and no-albuminuria (n=18) subgroups. Bilateral renal parenchymal 2D-SWV values were separately measured from upper, mid and lower portions. Groups were compared with T test or Mann-Whitney-U test as appropriate. Inter-reader agreement was assessed by intra-class correlation coefficient (ICC). Results: The median age [55.5 (50-62) vs 55 (48.5-59.5) years, respectively, p=0.48] and gender rates [18 (45%) vs 10 (58.8%) females, respectively, p= 0.34] did not differ between DM-II and control groups. The average and individual portion 2D-SWV values were also similar (p>0.05 for all). The average 2D-SWV values were also similar between the albuminuria vs no-albuminuria subgroups. The interobserver agreement was good (ICC: 0.66, 95% CI: 0.19-0.88, p=0.006). Conclusion: The kidney elasticity does not seem to be disturbed in patients with diabetes and a preserved eGFR with or without moderate albuminuria.

Peer review status:UNDER REVIEW

11 May 2021Submitted to International Journal of Clinical Practice
12 May 2021Assigned to Editor
12 May 2021Submission Checks Completed
03 Jun 2021Reviewer(s) Assigned