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Comparison of oral anticoagulant users with non-users admission laboratory parameters, length of hospital stay and outcomes in COVID-19 infection
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  • Faruk Karandere,
  • Mehmet Hursitoglu,
  • Erhan eroz,
  • Ecenur Bilgin,
  • Zeynep Karaali,
  • Betul Erismis,
  • Hakan Kocoglu,
  • Esra Canbolat Unlu,
  • Ramazan Korkusuz,
  • Halim Issever,
  • Kadriye Kart Yasar
Faruk Karandere
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Mehmet Hursitoglu
Basaksehir Cam and Sakura Sehir Hospital
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Erhan eroz
Basaksehir Cam and Sakura Sehir Hospital, university of Health Sciences
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Ecenur Bilgin
Basaksehir Cam and Sakura Sehir Hospital, university of Health Sciences
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Zeynep Karaali
Basaksehir Cam and Sakura Sehir Hospital, university of Health Sciences
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Betul Erismis
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Hakan Kocoglu
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Esra Canbolat Unlu
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Ramazan Korkusuz
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Halim Issever
Istanbul Medical Faculty
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Kadriye Kart Yasar
Bakirkoy Dr.Sadi Konuk Training and Research Hospital
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Abstract

Introduction Oral anticoagulants (OAs) are not in routine use during Coronavirus disease (COVID-19). Studies that compare the COVID-19 infection outcome of chronic OA users with their peers of non-OA users are available. To the best of our knowledge, none of these studies evaluated the effect of OA use on the COVID-19 related early admission laboratory parameters and/or length of the hospital stay. So, we will study these here. Methods  This retrospective study was included 2 groups; group 1 (n=62) consisted of OA users, and group 2 (n=75) of age, and sex-matched of OA non-users at the time of COVID-19 diagnosis. Early admission laboratory measures, numbers of comorbidities, length of hospital stay, and outcomes of these patients were recorded and analyzed Results Despite higher numbers of comorbidities in group 1, their serum CRP and D-dimer levels were significantly lower than the group 2. (p<0.05, all). The rate of mortality was higher in group 2 patients, but, it has not reached a statistical significance (p>0.05). Regression analysis showed that OA users (in comparison to non-OA users) had 0.980 and 0.520 times lower serum CRP and D-dimer levels, respectively.   Conclusions This study showed a beneficial effect of OA use on early admission serum CRP, and D-dimer levels, which are important prognostic predictors in COVID-19. Additionally, OA use associated with lesser hospital stay days of COVID-19 patients. These beneficial effects of OA use might help in improving the management of this infection after further dedicated studies in this field.

Peer review status:UNDER REVIEW

22 May 2021Submitted to International Journal of Clinical Practice
24 May 2021Assigned to Editor
24 May 2021Submission Checks Completed
05 Jun 2021Reviewer(s) Assigned