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Red Blood Cell Distribution Width in Patients with Chronic Obstructive Lung Diseases: Alteration due to Severity of Exacerbation
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  • Sumeyye Alparslan Bekir,
  • Eylem Acaturk,
  • Sinem Gungor,
  • Murat Yalcinsoy,
  • Ozlem Sogukpinar,
  • Baran Gundogus,
  • Emine Aksoy,
  • Meltem Agca,
  • Sinem Agca ,
  • Hatice Turker,
  • Zuhal Karakurt
Sumeyye Alparslan Bekir
University of Health Sciences Sureyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospita
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Eylem Acaturk
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Sinem Gungor
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Murat Yalcinsoy
Inonu University Faculty of Medicine
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Ozlem Sogukpinar
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Baran Gundogus
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Emine Aksoy
University of Health Sciences Sureyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital
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Meltem Agca
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Sinem Agca
Private Hospital
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Hatice Turker
Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital
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Zuhal Karakurt
Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital
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Abstract

Background: Elevated red blood cell distribution width (RDW) levels were associated with mortality in patients with stable chronic obstructive lung diseases (COPD). There are limited data about RDW levels in COPD exacerbation. Aim/Objective: The association of the RDW levels with the severity of the acute exacerbation of COPD (AECOPD) were evaluated according to admission location, (outpatient-clinic, ward and intensive care unit (ICU). Methods: Cross sectional retrospective study designed in tertiary chest dieases hospital. COPD patients admitted to hospital outpatiens-clinic, ward and ICU due to AECOPD were included. Patients demographics, RDW, C-reactive protein (CRP), biochemistry values were recorded. RDW values were subdivided below 0.11% (low), above and equal 0.15% (high) and between 0.11-0.15% (normal). Neutrophile to lymphocyte ratio (NLR) and platelet to mean platelet volume (PLT-MPV) were also calculated. Recorded values were compared according to where AECOPD was treated. Results: 2771 COPD patients (33% female) and 1429 outpatients-clinic, 1156 ward and 186 ICU were enrolled in the study. The median RWD values in outpatients-clinic, ward and ICU were 0.16 (0.09-0.26), 0.07 (0.01-0.14) and 0.01 (0.00-0.07) respectively (p<0.001). In outpatient to ward and ICU, low RDW values were significantly increased (31%, 66%, 83% respectively) and high RDW values significantly decreased (54%, 24%, 10%) (p<0.001). According to attack severity, low RDW values were determined. Conclusion: Patients with AECOPD, lower RDW values should be considered carefully. Lower RDW can be used for decision of COPD exacerbation severity and follow up treatment response. What is already known about this topic; In current studies, elevated RDW levels were associated with mortality in patients with stable COPD. What does this article add; Currently , there are limited data about RDW levels in COPD exacerbation. In the present study, the association of the RDW levels according to the severity of AECOPD were evaluated due to admission location.

Peer review status:IN REVISION

15 May 2021Submitted to International Journal of Clinical Practice
18 May 2021Assigned to Editor
18 May 2021Submission Checks Completed
06 Jun 2021Reviewer(s) Assigned
10 Jun 2021Review(s) Completed, Editorial Evaluation Pending
11 Jun 2021Editorial Decision: Revise Major