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Efficacy of Brucella abortus S19 and RB51 vaccine strains: a systematic review and meta-analysis
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  • Elaine Dorneles,
  • Marina Martins de Oliveira,
  • Carine Pereira,
  • Izabela Oliveira,
  • Jacques Godfroid,
  • Andrey Lage
Elaine Dorneles
Universidade Federal de Lavras Departamento de Medicina Veterinaria
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Marina Martins de Oliveira
Universidade Federal de Lavras Departamento de Medicina Veterinaria
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Carine Pereira
Universidade Federal de Lavras Departamento de Medicina Veterinaria
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Izabela Oliveira
Universidade Federal de Lavras Departamento De Ciencias Exatas
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Jacques Godfroid
UiT Norges arktiske universitet Institutt for arktisk og marin biologi
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Andrey Lage
Universidade Federal de Minas Gerais Escola de Veterinaria
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Abstract

This systematic review and meta-analysis aimed to recalculate the efficacy of these two vaccine strains, and to discuss the main variables associated with controlled trials to evaluate bovine brucellosis vaccines efficacy. The most used vaccine strain was S19, at the dose of 10 10 colony forming units (CFU), followed by the vaccine strain RB51 at 10 10 CFU. The most used challenge strain was B. abortus 2308, at the dose of 10 7 CFU by intraconjunctival route. For the meta-analysis, trials were grouped according to the vaccine strain and dose to recalculate protection against abortion (four groups) or infection (five groups), using pooled risk ratio (RR) and vaccine efficacy (VE). For protection against abortion (n = 15 trials), S19 vaccine at 10 9 CFU exhibited the highest protection rate (RR = 0.25, 95% CI: 0.12 to 0.52; VE = 75.09%, 95% CI: 48.08 – 88.05), followed by RB51 10 10 (RR = 0.31, 95% CI: 0.16 to 0.61; VE = 69.25%, 95% CI: 39.48 – 84.38). For protection against infection (n = 23 trials), only two subgroups exhibited significant protection: S19 at 10 9 CFU (RR = 0.28, 95% CI: 0.14 to 0.55; VE = 72.03%, 95% CI: 57.70 – 81.50) and RB51 at 10 10 CFU dose (RR = 0.43, 95% CI: 0.22 to 0.84; VE = 57.05%, 95% CI: 30.90 – 73.30). In conclusion, our results suggest that the dose of 10 9 CFU for S19 and 10 10 CFU for RB51 are the most suitable for the prevention of abortion and infection caused by B. abortus.

Peer review status:UNDER REVIEW

09 Jun 2021Submitted to Transboundary and Emerging Diseases
10 Jun 2021Assigned to Editor
10 Jun 2021Submission Checks Completed
11 Jun 2021Reviewer(s) Assigned