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1.Introduction: What is 5-Lipoxygenase and why we are interested in it?1.1   5-Lipoxygenase (5-LOX) affect the inflammatory reaction through phospholipid –arachidonic acid-leucotrienes pathway Eicosanoids are proinflammatory lipid mediators. Eicosanoid production is initiated by the release of arachidonic acid (AA) from membrane phospholipids by a calcium dependent cytosolic phospholipase A2 (cPLA2α)\cite{Leslie_2004}.The free AA can be metabolized into bioactive lipid mediators by two predominant pathways. Another metabolic pathway that can result in bioactive lipid mediators is the leukotriene pathway where AA is converted to leukotriene A4 (LTA4) by the action of 5- lipoxygenase (5-LO) and 5-LO-activating protein (FLAP).\cite{RN3}Leukotrienes (LTs) are mediators of inflammatory responses formed primarily in different types of leukocytes, and, in leukotriene biosynthesis, 5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) to leukotriene A4.\cite{RN34}5-lipoxygenase (5-LO) is a key enzyme in leukotriene biosynthesis\cite{R_dmark_1999} \cite{werz20005}.