Genetics & Genomics Next recognizes that the assessment of conceptual advance and potential utility and interest are subjective.  The journal’s editors therefore keep the following questions in mind when assessing a submitted manuscript and then provide specific explanation how these considerations apply to the selection of this particular manuscript.Initial Editorial AssessmentAvailable to authors of all manuscripts. Open if the article is publishedScopeDo the research, methods or topics fit within the aims of this, or another journal? Conceptual advanceWhat is already known in this area and related fields?What gap in knowledge motivates this research?How do the main claims of this study relate to benchmark prior publications?Is this field new, growing or mature?What new insight is offered by the current submission?If confirmatory, or a negative finding, what is the value added?Potential InterestAre many labs likely to conduct their research differently because of these findings?Is the paper likely attract readers beyond the immediate research community of the study?Can the main conclusion be generalized to other areas of genetics and genomics? Strength of conclusionWhat evidence and methods support the main claim of the study?Are the experimental and analytical approaches aligned with the current community standards?What are the technical issues with key datasets and workflows, what reviewer expertise is needed?Are the authors skeptical, are alternative interpretations ruled out?Is there clear separation of hypothesis generation and testing?Are conclusions replicated or supported by multiple lines of evidence? Reviewer instructions: All reviewer comments are read by the authors and editors, and are open if the article is publishedArticle types with data and analysis:Summarize the main claims in the context of prior publicationsIdentify the strengths and weaknesses in evidence, design and methodsPlease number each of your comments to the author, starting with the most importantAre all data, analysis and methods usefully available as declared in accordance with relevant community standards?Are there any ethical concerns about human or animal research subjects, perceived conflicts or attribution?How should the editor interpret your comments in making a decision?Declare your own conflicts of interest, or no conflict of interestPerspective (literature review) article type:Which of the main concepts and advances in the field has the author fairly represented?Will this Perspective lead a large number of researchers to conduct their research differently?Are the claims, evidence and recommendations presented in a clear and logical order?Declare your own conflicts of interest, or no conflict of interestAre all of the display items compelling or needed? 

To use the actual template to write an Article, please use this link: https://authorea.com/templates/article_template_for_genetics_genomics_nextSubmissions should be made via the online manuscript tracking system.  For technical help with the submission system, please contact ggn@wiley.com. Initial submission does not need to be formatted to Genetics & Genomics Next style  For ease of evaluation and submission, the journal recommends an editable Word .docx or Authorea text document and a single merged PDF that includes all parts of main text and high-resolution figures embedded into the file.  A suitable PDF will be constructed by uploading text and figures using the online manuscript tracking system.  Genetics & Genomics Next does not impose word count and figure limits.  Table 1 contains the journal’s suggestions so that the manuscript is respectful of reader time and are readable by specialist and generalist alike.AcknowledgementsAuthors should list all funding sources here, please check Open Funder Registry. Contributions and material support from anyone not listed as an author should be acknowledged here, with permission from the contributor. Thanks to anonymous reviewers are not allowed.Conflict of Interest StatementAll authors are required to declare if they have potential conflicts of interest related to the submission, or none. This declaration shall be published. Submitting authors shall confirm all co-authors agree with the final statement.AbstractWhat is known in the field, for a general readership. Define the area and knowledge for a specialist.Explain the motivation and need for the research defined by the gap in existing knowledge.State your main claim or finding . Support that with evidence, statistics and detail, mentioning essential methods and analytical techniques that provided the evidence.State the meaning and significance of your new results for research in the field.End by suggesting realistic immediate implications and uses of your findings in your field and more broadly.IntroductionGive credit to and cite all the primary research publications that lay the background to this work including those to be discussed in the Discussion. Give context as to whether these are essential methods and analytic strategies or experimental findings. Ensure that causation, correlation and conjectureResults Make the main claims in logical order, supported by display items and methodsDiscussion Summarize and evaluate the robustness and meaning of the main findings in light of existing publications. Be skeptical and discuss any limitations of the study and conditions where the results may or may not be applicableMaterials and MethodsMethods and materials transparencyOffer methods used in the analysis, and materials used to conduct the research to any researcher for purposes of reproducing the results or replicating the procedure.  Indicate any restrictions on analytic methods including software, and tools and study materials available to other researchers. Specify how, where and when that material will be available.  If an existing method or tool is used in the research, the authors are responsible for checking the license and state confirmation of permission.To obtain Research Resource Identifiers (RRIDs): Use the Resource Identification Portal .Design and analysis transparencyAuthors are encouraged to review standards for disclosing key aspects of the research design and data analysis at http://www.equator-network.org/ and use those that are relevant for their research. Research reporting standards are widely adopted in our field, and exceeding their evolving requirements is essential to sustain the impact of genetics and genomics for research and for society.  Here is the current list of reporting standards, vocabularies, models, schemas and databases that we recommend we recommend at FAIRsharing.org.Human studies and research participantsIdentify the ethics committee that approved the human study, and that the study conforms to recognized standards, for example: Declaration of Helsinki; US Federal Policy for the Protection of Human Subjects; or European Medicines Agency Guidelines for Good Clinical Practice. If no formal ethics committee is available, state that the research was carried out in accordance with recognized standards (e.g. the Declaration of Helsinki, as revised in 2013).Images and information from individual participants, including participants from patient registries and databases, will only be published where the authors have obtained the individual's free prior informed consent. Authors do not need to provide a copy of consent forms to the publisher but, in signing the author license to publish, authors are required to confirm that specific informed consent to publish the image has been obtained. Wiley has a standard patient consent form available for authors to use if required. This requirement to obtained informed consent applies whether or not patients are identifiable from the information presented in the submission.Animal studiesFor submissions involving animal studies, state the protocol and procedures employed were ethically reviewed and approved, and the name of the organization giving approval. State whether experiments were performed in accordance with relevant institutional and national guidelines and regulations for the care and use of laboratory animals:US authors should cite compliance with the US National Research Council's Guide for the Care and Use of Laboratory Animals, the US Public Health Service's Policy on Humane Care and Use of Laboratory Animals, and Guide for the Care and Use of Laboratory Animals.UK authors should conform to UK legislation under the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039).EU authors should conform to Directive 2010/63/EU.Cell line authentication Declare where the cells were obtained, whether the cell lines have been tested and authenticated and the method by which the cells were tested. If cells were obtained directly from a cell bank that performs cell line characterizations and passaged in the user’s laboratory for fewer than 6 months after receipt or resuscitation, re-authentication is not required. Data Availability StatementPlease choose text from Table 3 and provide a citation to available data in the References list. These sequence data have been submitted to the DDBJ/EMBL/GenBank databases under accession number XXXXX  Gene expression data (derived from microarrays or sequencing) has been deposited to a MIAME- or MINSEQE-compliant public repository like the Gene Expression Omnibus (GEO) with accession XXXXXProtein Sequence Data should be submitted to UniProt with accession XXXXXReferences [terms in brackets will be removed before publication]1. [article] Wood WG, Eckert GP, Igbavboa U, Muller WE. Statins and neuroprotection: a prescription to move the field forward. Ann N Y Acad Sci 2010; 1199:69-76. 2. [book] Hoppert, M. Microscopic techniques in biotechnology. Weinheim: Wiley-VCH; 2003.3. [dataset]Authors; Year; Dataset title; Data repository or archive; Version (if any); Persistent identifier (e.g. DOI)4. [URI, GWAS summary statistics] Savage, J.E. et al. Genome-wide association meta-analysis in 269,867      individuals identifies new genetic and functional links to intelligence      https://www.ebi.ac.uk/gwas/studies/GCST006250 (2018)5. [supplementary data] Jagadeesan, A. et al. MDS/PCA plots within West Africa    https://doi.org/10.6084/m9.figshare.5640931 (2017)Tables (each table complete with title and footnotes)      

A new method  \cite{Ludwig_2019} traces the cellular relationship and hierarchies (the “pedigrees”) of human cells within the body by reading the DNA sequences of hundreds to thousands of mitochondria extracted from single cells.Various genetic labeling techniques have been developed for lineage tracing in other model organisms. However, the above techniques are not applicable in intact humans. Cell lineage tracing is the most direct way to understand the development of complex cell types and their relationships in an organism, and an important method to trace abnormal cells over time to monitor developmental mosaicism, as demonstrated in C. elegans . In mammals, cell lineage tracing is particularly important for tracing cancer cells and their migration because cancers present special difficulties due to fast-paced proliferation and sequential genetic mutations. Lineage tracing can also determine if transplantation is successful and transplanted cells or tissues are on the correct site.The researchers showed that single-cell RNA sequencing (RNA-seq) and transposase accessible chromatin sequencing (ATAC-seq) methods could be used in combination to trace the inheritance of mitochondrial mutations, chromosomal states, and gene expressions at the same time, in multiple human cell colonies obtained from cultured cells, multiple human tissues, tumor cells, and transplanted cells.  ATAC-seq detects the regions of chromosomes that are not wrapped into nucleosomes by histone proteins, thus defining cellular or chromosomal states.  Using this method, they identified large numbers of mitochondrial DNA mutations and heteroplasmy (the presence of different types of mitochondrial genomes) that were associated with specific cell populations, tissues, or individuals. These experiments led to an important conclusion that mitochondrial mutations were inherited in the cellular colonies with extensive divisions stably and without being affected by cellular or chromosomal state, and the high mutation rate in mitochondrial DNA allows cellular sub-colonies to be traced with high resolution.Thus, the single-cell sequencing of mitochondrial DNA mutations provides a method that is much more accurate, stable, and affordable than a single-cell genome sequencing method to study clonal architecture in human health and diseases.Author ORCiDAlison Liu https://orcid.org/0000-0003-0171-6441