4) Is reduced brain activation in reward anticipation associated with anhedonia in the pre-adolescent stage? 
5) If abnormalities in ventral striatal activation to reward anticipation are present in the pre-adolescent stage, are they specific to any domain of psychopathology? In order to do this we used a single regression model  with averaged left and right nucleus accumbens reward anticipation as the outcome variable and separate predictor variables of psychotic like experience, depressive symptom score,  and anxiety total symptom score, in addition to covariates (age, sex, scanner site, BMI, etc). 
 

Methods

Subjects

A total of 3923 children aged 9-11 years from the ABCD dataset were initially included. These subjects were drawn from 21 centres throughout the US, with participants largely recruited through the school system. Sampling plans and recruitment procedures based on considerations of age, gender, race, socio-economic status and urbanicity were designed to reflect the sociodemographics of the US. Details of recruitment and study design are described elsewhere \cite{Garavan_2018}. Details of demographic, physical and mental health assessments are described elsewhere \citep{Barch_2018}
Data was taken from the "ABCD1.0 Release" \cite{abcd}. Task imaging data was available for 3179 subjects. Subjects with a diagnosis of ADHD, autism spectrum disorder, schizophrenia and intellectual disability were also excluded from analysis. Subjects who were under-weight as defined by CDC \cite{charts} were also excluded. Subjects were also excluded based on poor task performance.  Finally a total of 2129 subjects were ultimately included in the analysis. A breakdown of demographic data is described in Table \ref{421683}.