Matching: Control participants were matched to the patient group based on age and sex. Patients were split by sex and in nine age bins, resulting in 18 subgroups (table S1). Nine age bins (as opposed to any other number between 2 and 40) proved to result in the highest number of participants whilst retaining optimal comparability in terms of age and sex between patients and controls. Nonetheless, the matching was only partially successful due to inherent differences in sample composition.