Afterwards this list was exported to Excel to divide the studies in categories (Table 1). As first step, only studies of the last 10 years were kept (2010-2020), remaining a total amount of 97 papers . Then, the works were divided based on the type of journal of publication, multidisciplinary or biology, giving score 1 or 2 respectively. Subsequently, studies involving the treatment of implantable systems were discarded ( i.e. coatings of prosthesis). Next, abstract and introductions were been read to verify if human-derived (73.3%) or animal-derived (26.8%) cells were used. Finally, works were sorted by application of advanced systems. In detail, there was the 28.9% of works that used basic 2D cultures, 16.5% that used cell spheroids or microaggregates, 43.3% of papers that used hydrogels or biofabricated scaffolds and finally the 11.3% that used other types of advanced systems as bioreactors, microgravity or microfluidic chips.