This Authorea document template can be used to prepare documents according to a desired citation style and authoring guidelines. Abstracts are not always required, but most academic papers have one and writers should know how to produce a useful abstract. An abstract should be a very short, clear and concise summation of the entire paper.
An abstract should provide enough of a preview that a typical reader will know whether or not they wish to read the paper. It should reveal both the purpose and conclusions of the paper.

Introduction

The format of this template follows a typical journal publication with an introduction, results and conclusion. Examples of an equation, list and citation are also included. 

The purpose of the introduction

Most academic introductions follow an ‘inverted pyramid’ structure: they start broad and narrow down to a specific thesis or research question. The introduction should reveal:
  1. some broad knowledge of the overall topic
  2. references to related and prior work in the field of investigation
  3. succinct overview of the major point of the paper

Results

This section is only included in papers that rely on primary research. This section catalogues the results of the experiment. The results should be presented in a clear and unbiased way. Most results sections will contain links and citations, e.g., \cite{Feynman_1986}, and equations, e.g. \(e^{i\pi}+1=0\).

Conclusion

MMPs Como blanco terapeutico en preeclampsia

Matrix metalloproteinase-14 (MMP-14 also known as MT1-MMP) is an protease that it has been identified in syncytiotrophoblast and its responsible regulating the soluble endoglin release in placenta. The soluble endoglin is upregulated in preeclampsia, associated with dysfunction endothelial and their clinics manifestations.

El amplio estudio de las MMPs, han postulado a esta familia de proteasas como importantes blancos terapéuticos en la patología de la preeclampsia.  La metaloproteasa de matriz extracelular- 14 (MMP-14, también conocida como MT1-MMP) se ha identificado en sincitiotrofoblasto como responsable de regular la secreción de endoglina soluble, proteína anti-angiogénica, asociada con la disfunción endotelial y manifestaciones clínicas de la preeclampsia severa [1, 2] . 

 
 
1. Kaitu'u-Lino, T. J.; Palmer, K. R.; Whitehead, C. L.; Williams, E.; Lappas, M.; Tong, S., MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin. The American journal of pathology 2012, 180, (3), 888-94.
2. Kaitu'u-Lino, T. J.; Tuohey, L.; Ye, L.; Palmer, K.; Skubisz, M.; Tong, S., MT-MMPs in pre-eclamptic placenta: relationship to soluble endoglin production. Placenta 2013, 34, (2), 168-73.