The research, conducted with the model plant Arabidopsis thaliana and published in the journal PLOS Genetics, has discovered a key gene -HsfA2-, which activates the chaperone synthesis and thus rescues the cell from the toxic effects produced by misfolded protein accumulations. "The signaling pathway from the chloroplasts to the nucleus turns on a molecular switch called HsfA2. This key gene is also activated when a heat stroke causes problems of protein folding in other cellular compartments, "explains Ernesto Llamas, the first author of the work.