Changes in lipid profile are well established in patients with dengue immunological factors as cytokines have been proposed as the cause of these circulating lipid alterations. We investigate the association between serum lipid levels and circulating serum levels of TNF-α in dengue patients from an endemic region in the northwest of Mexico. Significant differences were observed in serum lipid profile in patients with dengue infection. Indee an increased in mean TNF-αvalue were observed in patients with dengue infection compared to a healthy control group. Nevertheless statistically TNF-α level did not correlate with lipids levels in patients with dengue.