Module-Specific Time-Dependent Variation in ISC and ISFC. The normalized ISC (purple) and ISFC (blue) curves for the seven network modules, ordered from greatest to least difference between ISC and ISFC in the shape of the curve. Broadly, we observed a significant difference between normalized ISC and normalized ISFC on day three and day four, particularly for the SM, VIS, DMN and AUD modules. These differences occurred as ISC significantly decreased with training while ISFC remained high.