Measuring intersubject connectivity and intersubject functional connectivity. a, To measure intersubject connectivity (ISC), the mean time series of a single node is extracted in each subject (four subject shown here). b, Next, the correlation between all pairs of subjects’ timeseries is calculated. The mean of all entries (black box) is the node’s ISC. The mean of a subject’s row (blue box) is the subject’s ISC. c, To measure intersubject functional connectivity for a single subject (4) and node i, the functional connectivity between node i and all other nodes j is calculated for each subject. Next, the mean connectivity between i and all other nodes j is calculated without subject 4 (black box). ISFC for subject 4 and node i, then, is the correlation between the mean connectivity between i and all other nodes j the connectivity between i and all other nodes j in subject 4.