Reducing the system to the one variable we are studying is useful but dangerous. We can find correlations and infer causation too easily. Really important contribution to our understanding of the relationship between sensory integration and behavior. Important moving forward with new research. These results will likely shape the way we interpret and develop new strategies to tackle questions in systems neuroscience.
This paper is very timely with the discussion going on in systems neuroscience. New pupil results showing how it correlates with sensory representation.
This study is attempting to look at a wider range of variables and a wider area of the brain all at once.
Widefield calcium imaging of the whole dorsal cortical surface.
Multimodal decision-making task. Two cohorts of mice either trained on auditory or visual tasks (but not both). Delayed response to report target.
Is there a reason why you have two handles?
How long does it takes to the mice to generalize to the non-trained?
Why not big V1 increase in Stim 2? What does white field give you? Dendrites? Cortico-cortical connections dominating. Discuss what you are seeing here.
What happens in AC?
"model variables that were associated with animal movement or internal state (‘Movement’) contained particularly high predictive power compared to task-related variables (‘Task’)". Question. Is it possible that movement explains a lot because there is a lot of movement in the trial epoch? The task is not that complex and does not require integration or memory retantion. I need to look more carefully into this one.
Is right the reference? for Fig1?
Can you just show the time course? Most of the trial is about movement.
What is the motivation for focusing on retrosplenial cortex?
Task shared and task independent is not clear.
Movement-related and task-related variables seem to have different temporal dynamics: movement-related variables change more quickly than task-related variables. Is there a way to control for this when predicting neural activity?
Pupil changes slowly so there is no way it can explain fast fluctuations in the Ca imaging in ALM. Average Ca signal per trial or doing a coherence analysis (in Reimier paper?).