Kaeberlein, M., McVey, M., and Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999; 13: 2570–2580
Kanfi, Y., Peshti, V., Gil, R., Naiman, S., Nahum, L., Levin, E., Kronfeld-Schor, N., and Cohen, H.Y. SIRT6 protects against pathological damage caused by diet-induced obesity.Aging Cell. 2010; 9: 162–173
Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., and Cohen, H.Y. The sirtuin SIRT6 regulates lifespan in male mice. Nature. 2012; 483: 218–221
Kang, T.W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A. et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature. 2011; 479: 547–551
Kawahara, T.L., Michishita, E., Adler, A.S., Damian, M., Berber, E., Lin, M., McCord, R.A., Ongaigui, K.C., Boxer, L.D., Chang, H.Y., and Chua, K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.Cell. 2009; 136: 62–74
Kazak, L., Reyes, A., and Holt, I.J. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat. Rev. Mol. Cell Biol. 2012; 13: 659–671
Kenyon, C.J. The genetics of ageing. Nature. 2010; 464: 504–512
Kenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366: 461–464
Khrapko, K., Bodyak, N., Thilly, W.G., van Orsouw, N.J., Zhang, X., Coller, H.A., Perls, T.T., Upton, M., Vijg, J., and Wei, J.Y. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletionsNucleic Acids Res. 1999; 27: 2434–2441
Kim, E.B., Fang, X., Fushan, A.A., Huang, Z., Lobanov, A.V., Han, L., Marino, S.M., Sun, X., Turanov, A.A., Yang, P. et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011; 479: 223–227
Kippin, T.E., Martens, D.J., and van der Kooy, D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity.Genes Dev. 2005; 19: 756–767
Kirkwood, T.B. Understanding the odd science of aging. Cell. 2005; 120: 437–447
Kirkwood, T.B. A systematic look at an old problem. Nature. 2008; 451: 644–647
Klass, M.R. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech. Ageing Dev. 1983; 22: 279–286
Koga, H., Kaushik, S., and Cuervo, A.M. Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res. Rev. 2011; 10: 205–215
Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., and Sharpless, N.E. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 2004; 114: 1299–1307
Krishnan, V., Chow, M.Z., Wang, Z., Zhang, L., Liu, B., Liu, X., and Zhou, Z. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. USA. 2011; 108: 12325–12330
Kroemer, G., Galluzzi, L., and Brenner, C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007; 87: 99–163
Kruegel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J.R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S., Murakami, C.J., Schleit, J. et al. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet. 2011; 7: e1002253
Kuilman, T., Michaloglou, C., Mooi, W.J., and Peeper, D.S. The essence of senescence. Genes Dev. 2010; 24: 2463–2479
Kujoth, G.C., Hiona, A., Pugh, T.D., Someya, S., Panzer, K., Wohlgemuth, S.E., Hofer, T., Seo, A.Y., Sullivan, R., Jobling, W.A. et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.Science. 2005; 309: 481–484
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P. et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127: 1109–1122
Lamming, D.W., Ye, L., Katajisto, P., Goncalves, M.D., Saitoh, M., Stevens, D.M., Davis, J.G., Salmon, A.B., Richardson, A., Ahima, R.S. et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335: 1638–1643
Laplante, M. and Sabatini, D.M. mTOR signaling in growth control and disease. Cell. 2012; 149: 274–293
Larson, K., Yan, S.J., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., Guo, D., Eickbush, T.H., and Li, W.X. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 2012; 8: e1002473
Laurie, C.C., Laurie, C.A., Rice, K., Doheny, K.F., Zelnick, L.R., McHugh, C.P., Ling, H., Hetrick, K.N., Pugh, E.W., Amos, C. et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat. Genet. 2012; 44: 642–650
Lavasani, M., Robinson, A.R., Lu, A., Song, M., Feduska, J.M., Ahani, B., Tilstra, J.S., Feldman, C.H., Robbins, P.D., Niedernhofer, L.J., and Huard, J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat. Commun. 2012; 3: 608
Lee, I.H., Cao, L., Mostoslavsky, R., Lombard, D.B., Liu, J., Bruns, N.E., Tsokos, M., Alt, F.W., and Finkel, T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Proc. Natl. Acad. Sci. USA. 2008; 105: 3374–3379
Lee, B.H., Lee, M.J., Park, S., Oh, D.C., Elsasser, S., Chen, P.C., Gartner, C., Dimova, N., Hanna, J., Gygi, S.P. et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010; 467: 179–184
Lee, J.S., Ward, W.O., Ren, H., Vallanat, B., Darlington, G.J., Han, E.S., Laguna, J.C., DeFord, J.H., Papaconstantinou, J., Selman, C., and Corton, J.C. Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mech. Ageing Dev. 2012; 133: 467–478
Lefebvre, J.S., Maue, A.C., Eaton, S.M., Lanthier, P.A., Tighe, M., and Haynes, L. The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice. Aging Cell. 2012; 11: 732–740
Linnane, A.W., Marzuki, S., Ozawa, T., and Tanaka, M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1989; 1: 642–645
Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J. et al. Genomic instability in laminopathy-based premature aging.Nat. Med. 2005; 11: 780–785
Liu, G., Rogers, J., Murphy, C.T., and Rongo, C. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.EMBO J. 2011; 30: 2990–3003
Liu, G.H., Suzuki, K., Qu, J., Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R.D. et al. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011; 8: 688–694