the 5-LO pathway has also been associated with atherosclerosis\cite{Mehrabian_2003}\cite{De_Caterina_2004}\cite{Radmark_2003}, osteoporosis \cite{Gallwitz19935}and certain types of cancer like neuroblastoma \cite{van_Rossum_2002} and prostate cancer\cite{Ghosh_1998}

Phosphorylation as a mechanism responsible for the translocation of apoptotic mediators to the perinuclear membrane in response to oxidative stress is not restricted to 5LO.  \cite{Ye_2008}   

 

 

5.EXtra:

Ca2+, the cellular peroxide tonus, phosphorylation, binding of PC and/or DAGs seem to regulate the activity of 5-LO in a complex manner\cite{Werz_2005}

the potency of several nonredox-type 5-LO inhibitors like ZM 230487 or the related Merck compound L-739,010 (but not of redox-type 5-LO inhibitors) in intact cells depends on the stimulus and the phosphorylation status of the 5-LO enzyme \cite{Fischer_2003}. Thus, 5-LO product formation involving 5-LO kinase pathways require 10-to 100-fold higher concentrations of ZM 230487 or L-739,010 for comparable 5-LO inhibition versus Ca2+-mediated 5-LO activation using ionophore as stimulus,phosphorylation events seem to impair the potency of some but not all nonredox-type inhibitors of 5-LO.